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    lem2 LEM domain nuclear inner membrane protein Heh1/Lem2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542544, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lem2
    Official Full Name
    LEM domain nuclear inner membrane protein Heh1/Lem2
    Primary source
    PomBase:SPAC18G6.10
    Locus tag
    SPOM_SPAC18G6.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    heh1
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    Genomic context

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    See lem2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2234278..2236773)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene rRNA (pseudouridine) methyltransferase Mra1 Neighboring gene protein Edc1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase I general transcription inititation factor subunit Rrn3 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear membrane protein Lem2 regulates nuclear size through membrane flow. Kume K, et al. Nat Commun, 2019 Apr 23. PMID 31015410, Free PMC Article
    2. Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina. Gonzalez Y, et al. Nucleus, 2012 Jan-Feb. PMID 22540024, Free PMC Article
    3. Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum. Hirano Y, et al. Commun Biol, 2020 Jun 1. PMID 32483293, Free PMC Article
    4. The functionally elusive RabI chromosome configuration directly regulates nuclear membrane remodeling at mitotic onset. Fernández-Álvarez A, et al. Cell Cycle, 2017 Aug 3. PMID 28678660, Free PMC Article
    5. Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing. Banday S, et al. J Biol Chem, 2016 Sep 16. PMID 27451393, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum.
      Title: Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum.
    2. Study propose that Schizosaccharomyces pombe Lem2 forms part of a nuclear size control mechanism, acting as a barrier to membrane flow into and out of the nuclear envelope. Lem2 deletion leads to nuclear shrinkage, accompanied by nuclear envelope blebbing, following perturbation of membrane synthesis and the ER protein Lnp1 acts as a secondary barrier, compensating for lack of Lem2.
      Title: Nuclear membrane protein Lem2 regulates nuclear size through membrane flow.
    3. Study shows that Lem2 is retained at the nuclear envelope through its interaction with Bqt4, as the loss of Bqt4 results in the exclusive accumulation of Lem2 to the spindle pole body. An N-terminal nucleoplasmic region of Lem2 bears affinity to both Bqt4 and the SPB in a competitive manner.
      Title: Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast.
    4. Lem2 and Man1 proteins of the fission yeast Schizosaccharomyces pombe perform fundamental functions of the animal cell lamina [Lem2][Man1]
      Title: Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina.
    5. A combination of mutations in Lem2 and Bqt4, which encodes a nuclear membrane protein that anchors telomeres to the nuclear membrane, caused synthetic lethality. These genetic interactions imply that Lem2 cooperates with the nuclear membrane protein network to regulate genome stability
      Title: Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions.
    6. in Schizosaccharomyces pombe, the nuclear membrane protein Lem2 associates with chromatin and mediates silencing and heterochromatin localization
      Title: Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables centromere-nuclear envelope anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables centromeric DNA binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heterochromatin-nuclear membrane anchor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables heterochromatin-nuclear membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of telomeric heterochromatin to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centromere clustering at the mitotic interphase nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic nuclear membrane reassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear inner membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subnuclear spatial organization of silent mating-type cassette heterochromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in CENP-A containing chromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in CENP-A containing chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric core domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic nuclear bridge midzone membrane domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear inner membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LEM domain nuclear inner membrane protein Heh1/Lem2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2234278..2236773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019105.3 → NP_593673.1  LEM domain nuclear inner membrane protein Heh1/Lem2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593673.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10109
      Conserved Domains (2) summary
      pfam09402
      Location:326 → 666
      MSC; Man1-Src1p-C-terminal domain
      pfam12949
      Location:11 → 45
      HeH; HeH/LEM domain
    Nucleotide Protein
    Heading Accession and Version

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