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    IRC6 Irc6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850604, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IRC6
    Official Full Name
    Irc6p
    Primary source
    SGD:S000001939
    Locus tag
    YFR043C
    See related
    AllianceGenome:SGD:S000001939; FungiDB:YFR043C; VEuPathDB:YFR043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in vesicle-mediated transport. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IRC6 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (239114..239827, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Erj5p Neighboring gene Keg1p Neighboring gene metallodipeptidase Neighboring gene Mrx20p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clathrin Adaptor Complex-interacting Protein Irc6 Functions through the Conserved C-Terminal Domain. Zhou H, et al. Sci Rep, 2019 Mar 14. PMID 30872642, Free PMC Article
    2. Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. Gorynia S, et al. Mol Biol Cell, 2012 Nov. PMID 22993212, Free PMC Article
    3. Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance. Bilsland E, et al. Mol Microbiol, 2004 Sep. PMID 15341652
    4. De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Zhang W, et al. Genes Dev, 2010 Mar 1. PMID 20194442, Free PMC Article
    5. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. Alvaro D, et al. PLoS Genet, 2007 Dec. PMID 18085829, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Irc6p/p34 functions as a novel type of conserved clathrin accessory protein and founding member of a new G protein-like family.
      Title: Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Irc6p
    NP_116701.3
    • Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      239114..239827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180008.3 → NP_116701.3  TPA: Irc6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116701.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTS6, P43615
      UniProtKB/TrEMBL
      G2WDI4, N1PA12
      Conserved Domains (1) summary
      pfam10199
      Location:162 → 232
      Adaptin_binding; Alpha and gamma adaptin binding protein p34
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43615.1

    Gene LinkOut

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