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    FUI1 uridine permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852238, updated on 1-Aug-2024

    Summary

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    Gene symbol
    FUI1
    Gene description
    uridine permease
    Primary source
    FungiDB:YBL042C
    Locus tag
    YBL042C
    See related
    SGD:S000000138; AllianceGenome:SGD:S000000138; VEuPathDB:YBL042C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables uridine transmembrane transporter activity. Involved in transmembrane transport and uridine transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FUI1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (138341..140260, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ecm13p Neighboring gene proteasome core particle subunit beta 6 Neighboring gene Erd2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the transport mechanism and permeant binding profile of the uridine permease Fui1p of Saccharomyces cerevisiae. Zhang J, et al. J Biol Chem, 2006 Sep 22. PMID 16854981
    2. The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein. De Wergifosse P, et al. Yeast, 1994 Nov. PMID 7871888
    3. Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Blondel MO, et al. Mol Biol Cell, 2004 Feb. PMID 14657252, Free PMC Article
    4. Only one of the charged amino acids located in membrane-spanning regions is important for the function of the Saccharomyces cerevisiae uracil permease. Pinson B, et al. Biochem J, 1999 Apr 1. PMID 10085225, Free PMC Article
    5. The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease. Wagner R, et al. FEMS Microbiol Lett, 1998 Feb 1. PMID 9485596

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleobase transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in uridine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uridine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uridine permease
    NP_009511.1
    • High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      138341..140260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178282.1 → NP_009511.1  TPA: uridine permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009511.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPV6, P38196
      UniProtKB/TrEMBL
      C7GNC0, G2W8W5, N1P8Z3
      Conserved Domains (1) summary
      cd11482
      Location:112 → 593
      SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38196.1

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