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    SHC1 Shc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856832, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SHC1
    Official Full Name
    Shc1p
    Primary source
    SGD:S000000898
    Locus tag
    YER096W
    See related
    AllianceGenome:SGD:S000000898; FungiDB:YER096W; VEuPathDB:YER096W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme activator activity. Involved in ascospore formation and chitin biosynthetic process. Located in prospore membrane. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SHC1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (351698..353236)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 3 Neighboring gene recombinase RAD51 Neighboring gene tRNA-Glu Neighboring gene putative ubiquitin-specific protease UBP9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SHC1, a high pH inducible gene required for growth at alkaline pH in Saccharomyces cerevisiae. Hong SK, et al. Biochem Biophys Res Commun, 1999 Feb 5. PMID 10082665
    2. Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation. Sanz M, et al. Mol Microbiol, 2002 Mar. PMID 11918806
    3. Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae. Hoffmann R, et al. Genetics, 2017 Dec. PMID 28978675, Free PMC Article
    4. Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis. Iwamoto MA, et al. Eukaryot Cell, 2005 Mar. PMID 15755916, Free PMC Article
    5. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Huang D, et al. Mol Cell Biol, 2002 Jul. PMID 12077337, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Shc1p
    NP_011022.1
    • Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      351698..353236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178987.1 → NP_011022.1  TPA: Shc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM04, P39000
      UniProtKB/TrEMBL
      B3LRL5, C7GRT0, C8Z7B5
      Conserved Domains (3) summary
      smart00671
      Location:354 → 389
      SEL1; Sel1-like repeats
      COG0790
      Location:304 → 493
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:302 → 330
      SLR; SLR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39000.1

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