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    est1 telomerase regulator Est1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540492, updated on 18-Sep-2024

    Summary

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    Official Symbol
    est1
    Official Full Name
    telomerase regulator Est1
    Primary source
    PomBase:SPBC2D10.13
    Locus tag
    SPOM_SPBC2D10.13
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See est1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2988586..2990276)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene nucleosome assembly protein Nap2 Neighboring gene ncRNA Neighboring gene UV excision repair protein rhp23 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myosin type V

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Telomere maintenance in fission yeast requires an Est1 ortholog. Beernink HT, et al. Curr Biol, 2003 Apr 1. PMID 12676088
    2. TER1, the RNA subunit of fission yeast telomerase. Leonardi J, et al. Nat Struct Mol Biol, 2008 Jan. PMID 18157152
    3. Identification and characterization of the Schizosaccharomyces pombe TER1 telomerase RNA. Webb CJ, et al. Nat Struct Mol Biol, 2008 Jan. PMID 18157149, Free PMC Article
    4. Fission yeast Ccq1 is a modulator of telomerase activity. Armstrong CA, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29216371, Free PMC Article
    5. Telomerase activation after recruitment in fission yeast. Armstrong CA, et al. Curr Biol, 2014 Sep 8. PMID 25131669, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables enzyme activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere-telomerase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    part_of telomerase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomerase regulator Est1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2988586..2990276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022152.3 → NP_596232.1  telomerase regulator Est1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596232.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74804
      Conserved Domains (2) summary
      pfam10373
      Location:195 → 450
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:64 → 184
      EST1; Telomerase activating protein Est1
    Nucleotide Protein
    Heading Accession and Version

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