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    RRP15 Rrp15p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856264, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RRP15
    Official Full Name
    Rrp15p
    Primary source
    SGD:S000006347
    Locus tag
    YPR143W
    See related
    AllianceGenome:SGD:S000006347; FungiDB:YPR143W; VEuPathDB:YPR143W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RRP15 (ribosomal RNA processing 15 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RRP15 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (818323..819075)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase Neighboring gene Kar3p Neighboring gene tRNA-Ile Neighboring gene ribosome biosynthesis protein NOC4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modular assembly of the nucleolar pre-60S ribosomal subunit. Sanghai ZA, et al. Nature, 2018 Apr 5. PMID 29512650, Free PMC Article
    2. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Lum PY, et al. Cell, 2004 Jan 9. PMID 14718172
    3. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. De Marchis ML, et al. RNA, 2005 Apr. PMID 15769876, Free PMC Article
    4. The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Saveanu C, et al. Mol Cell Biol, 2007 Apr. PMID 17308036, Free PMC Article
    5. Translation initiation factor eIF4G1 modulates assembly of the polypeptide exit tunnel region in yeast ribosome biogenesis. Tseng YT, et al. J Cell Sci, 2022 Jun 15. PMID 35615984

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rrp15p
    NP_015469.1
    • Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      818323..819075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184240.1 → NP_015469.1  TPA: Rrp15p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015469.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4E0, Q06511
      UniProtKB/TrEMBL
      A6ZX19, B3LKA3, C7GLK2, C8ZJG6, G2WPV6, N1NW57
      Conserved Domains (1) summary
      pfam07890
      Location:112 → 242
      Rrp15p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06511.1

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