U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    BAG7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854302, updated on 22-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    BAG7
    Primary source
    FungiDB:YOR134W
    Locus tag
    YOR134W
    See related
    SGD:S000005660; AllianceGenome:SGD:S000005660; VEuPathDB:YOR134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in negative regulation of Rho protein signal transduction and positive regulation of GTPase activity. Predicted to be active in cell cortex. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See BAG7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (578564..579793)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene retromer subunit VPS17 Neighboring gene elongation factor 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2 Neighboring gene Sia1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Schmidt A, et al. Mol Microbiol, 2002 Sep. PMID 12207708
    2. Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Lorberg A, et al. Mol Genet Genomics, 2001 Nov. PMID 11713681
    3. Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. Roumanie O, et al. FEBS Lett, 2001 Oct 5. PMID 11591390
    4. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Schmidt A, et al. Cell, 1997 Feb 21. PMID 9038344
    5. Cadmium induces the activation of cell wall integrity pathway in budding yeast. Xiong B, et al. Chem Biol Interact, 2015 Oct 5. PMID 26362500

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    GTPase-activating protein BAG7
    NP_014777.3
    • Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      578564..579793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183553.3 → NP_014777.3  TPA: GTPase-activating protein BAG7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014777.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2J2, Q12128
      UniProtKB/TrEMBL
      A6ZNY1, B3LJH6, B5VS23, C7GN87, C8ZI96, N1P368
      Conserved Domains (1) summary
      cd04396
      Location:47 → 257
      RhoGAP_fSAC7_BAG7; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12128.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous