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    lsd1 histone demethylase SWIRM1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lsd1
    Official Full Name
    histone demethylase SWIRM1
    Primary source
    PomBase:SPBC146.09c
    Locus tag
    SPOM_SPBC146.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    saf110; swm1
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    Genomic context

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    See lsd1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1015936..1019241, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U2 small nuclear RNA auxiliary factor small subunit, U2AF-59 Neighboring gene ncRNA Neighboring gene translation initiation factor eIF1A-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein mug57 Neighboring gene protein mug97

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Cross-Regulation Between Set1, Clr4, and Lsd1/2 in Schizosaccharomyces pombe. Liu H, et al. PLoS Genet, 2024 Jan. PMID 38181050, Free PMC Article
    2. Dicer promotes transcription termination at sites of replication stress to maintain genome stability. Castel SE, et al. Cell, 2014 Oct 23. PMID 25417108, Free PMC Article
    3. Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast. Holmes A, et al. Cell Rep, 2012 Dec 27. PMID 23260662, Free PMC Article
    4. Molecular signature of the imprintosome complex at the mating-type locus in fission yeast. Raimondi C, et al. Microb Cell, 2018 Jan 16. PMID 29610759, Free PMC Article
    5. Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1. Opel M, et al. PLoS One, 2007 Apr 18. PMID 17440621, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables FAD-dependent H3K4me/H3K4me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9me/H3K9me2 demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables promoter-specific chromatin binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in facultative heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating-type locus imprinting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of replication fork arrest at rDNA repeats IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest at mating type locus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Lsd1/2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus NAS
    Non-traceable Author Statement
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone demethylase SWIRM1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1015936..1019241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021305.3 → NP_595398.1  histone demethylase SWIRM1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595398.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTV0, Q9Y802
      Conserved Domains (3) summary
      pfam01593
      Location:267 → 755
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam04433
      Location:157 → 240
      SWIRM; SWIRM domain
      pfam13450
      Location:262 → 316
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version

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