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    NUT1 Nut1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852726, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NUT1
    Official Full Name
    Nut1p
    Primary source
    SGD:S000003119
    Locus tag
    YGL151W
    See related
    AllianceGenome:SGD:S000003119; FungiDB:YGL151W; VEuPathDB:YGL151W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED5; SSX4
    Summary
    Predicted to enable transcription coregulator activity. Involved in histone H3 acetylation; regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NUT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (217524..220922)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene holo-[acyl-carrier-protein] synthase Neighboring gene Pex14p Neighboring gene chromatin-remodeling ATPase INO80 Neighboring gene uncharacterized protein Neighboring gene bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes. Sylvain MA, et al. Genetics, 2011 Jul. PMID 21515579, Free PMC Article
    2. Functional studies of the yeast med5, med15 and med16 mediator tail subunits. Larsson M, et al. PLoS One, 2013. PMID 23991176, Free PMC Article
    3. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975
    4. The structural and functional role of Med5 in the yeast Mediator tail module. Béve J, et al. J Biol Chem, 2005 Dec 16. PMID 16230344
    5. Association of the Mediator complex with enhancers of active genes. Kuras L, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14623974, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nut1/Hos1 and Sas2/Rpd3 control the H3 acetylation of two different sets of osmotic stress-induced genes.
      Title: Nut1/Hos1 and Sas2/Rpd3 control the H3 acetylation of two different sets of osmotic stress-induced genes.
    2. The analysis has identified the Med5 subunit of Mediator as a target for histone tail interactions and suggests that the previously observed effect of med5 mutations on telomeric heterochromatin and silencing is direct.
      Title: Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions.
    3. Med5 has a role in coordinating nuclear and mitochondrial gene transcription
      Title: The structural and functional role of Med5 in the yeast Mediator tail module.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nut1p
    NP_011364.1
    • Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      217524..220922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181016.1 → NP_011364.1  TPA: Nut1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011364.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTZ9, P53114
      UniProtKB/TrEMBL
      N1P4Q4
      Conserved Domains (1) summary
      pfam08689
      Location:1 → 1127
      Med5; Mediator complex subunit Med5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53114.1

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