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    IMP4 snoRNA-binding rRNA-processing protein IMP4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855649, updated on 9-Jun-2024

    Summary

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    Gene symbol
    IMP4
    Gene description
    snoRNA-binding rRNA-processing protein IMP4
    Primary source
    FungiDB:YNL075W
    Locus tag
    YNL075W
    See related
    SGD:S000005019; AllianceGenome:SGD:S000005019; VEuPathDB:YNL075W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA primary transcript binding activity; single-stranded telomeric DNA binding activity; and snoRNA binding activity. Involved in rRNA processing and ribosomal small subunit biogenesis. Part of Mpp10 complex and small-subunit processome. Orthologous to human IMP4 (IMP U3 small nucleolar ribonucleoprotein 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IMP4 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (485607..486479)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Apj1p Neighboring gene Mks1p Neighboring gene Mlf3p Neighboring gene lysine--tRNA ligase MSK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein. Hsieh YC, et al. Biochem J, 2007 Dec 15. PMID 17803460, Free PMC Article
    2. Schistosoma mansoni: the IMP4 gene is involved in DNA repair/tolerance after treatment with alkylating agent methyl methane sulfonate. Furtado C, et al. Exp Parasitol, 2007 May. PMID 17189633
    3. RNA chaperones stimulate formation and yield of the U3 snoRNA-Pre-rRNA duplexes needed for eukaryotic ribosome biogenesis. Gérczei T, et al. J Mol Biol, 2009 Jul 31. PMID 19482034, Free PMC Article
    4. Two-hybrid Mpp10p interaction-defective Imp4 proteins are not interaction defective in vivo but do confer specific pre-rRNA processing defects in Saccharomyces cerevisiae. Gallagher JE, et al. Nucleic Acids Res, 2004. PMID 14990745, Free PMC Article
    5. Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA. Gérczei T, et al. Proc Natl Acad Sci U S A, 2004 Oct 26. PMID 15489263, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Imp4p is a novel telomeric DNA-binding protein that, in addition to its role in rRNA processing, might participate in telomere function
      Title: The U3 small nucleolar ribonucleoprotein component Imp4p is a telomeric DNA-binding protein.
    2. Imp3p and Imp4p may help the small subunit processome to dock onto the pre-rRNA, an event indispensable for ribosome biogenesis and hence for cell growth
      Title: Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA primary transcript binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Mpp10 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snoRNA-binding rRNA-processing protein IMP4
    NP_014324.3
    • Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      485607..486479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182913.3 → NP_014324.3  TPA: snoRNA-binding rRNA-processing protein IMP4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014324.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A4, P53941
      UniProtKB/TrEMBL
      A0A8H4BW10, A6ZS05, B3LNT4, B5VQX0, C7GUM5, C8ZGF5, G2WM29
      Conserved Domains (1) summary
      COG2136
      Location:85 → 268
      IMP4; rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6KE6_5G.1
    6LQP_5G.1
    6LQQ_5G.1
    6LQR_5G.1
    6LQS_5G.1
    6LQT_5G.1
    6LQU_5G.1
    6LQV_5G.1
    6ZQG_CJ.1
    P53941.1

    Gene LinkOut

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