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    sst4 ESCRT 0 complex subunit sst4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542403, updated on 22-Jun-2024

    Summary

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    Gene symbol
    sst4
    Gene description
    ESCRT 0 complex subunit sst4
    Locus tag
    SPOM_SPAC19A8.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    vps27
    Old locus tag
    SPAC19A8.05c
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    Genomic context

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    See sst4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2477871..2480031)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Imp4 Neighboring gene putative dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-22 sterol desaturase Erg5 Neighboring gene ncRNA Neighboring gene myotubularin family phosphatidylinositol-3-phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. Onishi M, et al. Eukaryot Cell, 2007 Dec. PMID 17951524, Free PMC Article
    2. Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1. Wang YY, et al. EMBO J, 2021 Aug 2. PMID 34169534, Free PMC Article
    3. Ent3 and GGA adaptors facilitate diverse anterograde and retrograde trafficking events to and from the prevacuolar endosome. Yanguas F, et al. Sci Rep, 2019 Jul 24. PMID 31341193, Free PMC Article
    4. Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. Onishi M, et al. Biosci Biotechnol Biochem, 2003 Aug. PMID 12951513
    5. ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos. Liu XM, et al. Mol Cell, 2015 Sep 17. PMID 26365378

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sst4p is a downstream factor of PtdIns 3-kinase and functions in forespore membrane formation
      Title: Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein ligase activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore-type prospore assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT-0 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ESCRT 0 complex subunit sst4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2477871..2480031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019216.3 → NP_593787.1  ESCRT 0 complex subunit sst4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593787.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13821
      Conserved Domains (3) summary
      cd15735
      Location:168 → 226
      FYVE_spVPS27p_like; FYVE domain found in Schizosaccharomyces pombe vacuolar protein sorting-associated protein 27 (spVps27p) and similar proteins
      pfam02809
      Location:260 → 276
      UIM; Ubiquitin interaction motif
      cl02544
      Location:7 → 153
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials