MDV1 Mdv1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MDV1
Official Full Name: Mdv1p
Primary source: SGD:S000003648
Locus tag: YJL112W
See related: AllianceGenome:SGD:S000003648; FungiDB:YJL112W; VEuPathDB:YJL112W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAG3; NET2
Summary: Enables ubiquitin binding activity. Involved in mitochondrial fission; mitochondrial genome maintenance; and peroxisome fission. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MDV1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (205305..207449)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1
Title: A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment.
in addition to dimerization, the unusually long Mdv1 coiled coil serves a scaffolding function to stabilize the Mdv1-Fis1 complex.
Title: Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil.
Although deletion of Ty3 spacer domain dramatically reduced retrotransposition, significant Gag3 processing and cDNA synthesis occurred.
Title: The TY3 Gag3 spacer controls intracellular condensation and uncoating.
Mdv1 CC lies parallel to the bilayer with N termini at opposite ends bound to Fis1 and C-terminal beta-propeller domains (Dnm1-binding sites) extending into the cytoplasm
Title: Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Mdv1 played a postmitochondrial targeting role in division by interacting & coassembling with the GTP-bound form of Dnm1; this regulated interaction nucleated & promoted self-assembly of Dnm1 into helical structures which drive membrane scission
Title: Mechanistic analysis of a dynamin effector.
findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p; association of Caf4p and Mdv1p with peroxisomes relies on Fis1p
Title: Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.
the concave surface of the Fis1 tetratricopeptide repeat-like domain is evolutionarily conserved to bind the dynamin-like GTPase Dnm1 and not Mdv1 as previously predicted
Title: Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm.
Dnm1p dimers are initially recruited to the membrane via interaction with Mdv1p.Fis1p complexes
Title: Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.
the N terminus of Fis1 is a prerequisite to recruit Mdv1 to facilitate mitochondrial fission
Title: Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
dynamic interactions between Mdv1 and Dnm1 play a key role in division by regulating Dnm1 self-assembly
Title: Mdv1 interacts with assembled dnm1 to promote mitochondrial division.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mdv1p

NP_012423.1

Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

205305..207449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181545.2 → NP_012423.1 TPA: Mdv1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012423.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZQL5, D6VW72, P47025

UniProtKB/TrEMBL

G2WGQ7, N1P420

Conserved Domains (3) summary

cd00200
Location:397 → 713

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:402 → 439

7WD40; WD40 repeat [structural motif]

pfam11542
Location:123 → 171

Mdv1; Mitochondrial division protein 1