U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HIS6 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854792, updated on 3-Nov-2024

    Summary

    Official Symbol
    HIS6
    Official Full Name
    1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6
    Primary source
    SGD:S000001282
    Locus tag
    YIL020C
    See related
    AllianceGenome:SGD:S000001282; FungiDB:YIL020C; VEuPathDB:YIL020C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HIS6 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (314035..314820, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene protein translocase subunit TIM44 Neighboring gene DNA-directed RNA polymerase II core subunit RPB3 Neighboring gene Faf1p Neighboring gene ribosomal 60S subunit protein L2B

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-histidine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6
    NP_012244.3
    • Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      314035..314820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179370.3NP_012244.3  TPA: 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012244.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVQ9, P40545, Q6Q5P5
      UniProtKB/TrEMBL
      B3LTM8, B5VKS1, C7GPW8, C8ZAN0, G2WGC4, N1P0N3
      Conserved Domains (1) summary
      TIGR02129
      Location:2258
      hisA_euk; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic type