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    pcn1 DNA polymerase delta processivity factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540020, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pcn1
    Official Full Name
    DNA polymerase delta processivity factor
    Primary source
    PomBase:SPBC16D10.09
    Locus tag
    SPOM_SPBC16D10.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pcn
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    Genomic context

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    See pcn1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (3616595..3617845)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene heat shock protein Hsp104 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA specific adenosine-34 deaminase subunit Tad2 Neighboring gene 40S ribosomal protein uS13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Replication foci dynamics: replication patterns are modulated by S-phase checkpoint kinases in fission yeast. Meister P, et al. EMBO J, 2007 Mar 7. PMID 17304223, Free PMC Article
    2. Schizosaccharomyces pombe proliferating cell nuclear antigen mutations affect DNA polymerase delta processivity. Arroyo MP, et al. J Biol Chem, 1996 Jul 5. PMID 8663159
    3. Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation. Guarino E, et al. Nucleic Acids Res, 2011 Aug. PMID 21493688, Free PMC Article
    4. Functional analysis of subcellular localization and protein-protein interaction sequences in the essential DNA ligase I protein of fission yeast. Martin IV, et al. Nucleic Acids Res, 2004. PMID 14752051, Free PMC Article
    5. Histone chaperone networks shaping chromatin function. Hammond CM, et al. Nat Rev Mol Cell Biol, 2017 Mar. PMID 28053344, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCNA is ubiquitinated in response to DNA damage when cells are arrested in G2.(PCNA)
      Title: Postreplication repair and PCNA modification in Schizosaccharomyces pombe.
    2. These data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication.
      Title: Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables DNA polymerase processivity factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA polymerase processivity factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA strand elongation involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UV-damage excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in error-free translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication lagging strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA replication leading strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PCNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PCNA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase delta processivity factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3616595..3617845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022425.3 → NP_596504.1  DNA polymerase delta processivity factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596504.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q03392
      Conserved Domains (1) summary
      TIGR00590
      Location:1 → 258
      pcna; proliferating cell nuclear antigen (pcna)
    Nucleotide Protein
    Heading Accession and Version

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