RPN3 proteasome regulatory particle lid subunit RPN3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: RPN3
Official Full Name: proteasome regulatory particle lid subunit RPN3
Primary source: SGD:S000000823
Locus tag: YER021W
See related: AllianceGenome:SGD:S000000823; FungiDB:YER021W; VEuPathDB:YER021W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SUN2
Summary: Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RPN3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (196948..198519)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the availability of Rpn11 is important for maintaining adequate levels of intact proteasomes, as its depletion caused growth and proteolytic defects in rpn3.
Title: A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: proteasome regulatory particle lid subunit RPN3

NP_010938.1

Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

196948..198519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178912.1 → NP_010938.1 TPA: proteasome regulatory particle lid subunit RPN3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010938.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLS0, P40016

UniProtKB/TrEMBL

A6ZQX0, G2WCQ4, N1P5S1

Conserved Domains (2) summary

pfam01399
Location:343 → 447

PCI; PCI domain

pfam08375
Location:450 → 509

Rpn3_C; Proteasome regulatory subunit C-terminal