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    GUA1 GMP synthase (glutamine-hydrolyzing) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855257, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GUA1
    Official Full Name
    GMP synthase (glutamine-hydrolyzing)
    Primary source
    SGD:S000004830
    Locus tag
    YMR217W
    See related
    AllianceGenome:SGD:S000004830; FungiDB:YMR217W; VEuPathDB:YMR217W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GMP synthase (glutamine-hydrolyzing) activity. Involved in GMP biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GUA1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (701790..703367)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative 1,3-beta-glucanosyltransferase Neighboring gene serine/threonine protein kinase SKY1 Neighboring gene transport protein particle complex II subunit TRS130 Neighboring gene Esc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Gardner WJ, et al. Can J Microbiol, 1979 Mar. PMID 222417
    2. Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Dujardin G, et al. Gene, 1994 Feb 11. PMID 8112582
    3. Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Escobar-Henriques M, et al. Mol Cell Biol, 2003 Sep. PMID 12917348, Free PMC Article
    4. Transcriptional regulation of the yeast gmp synthesis pathway by its end products. Escobar-Henriques M, et al. J Biol Chem, 2001 Jan 12. PMID 11035032
    5. Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway. Mechoud MA, et al. Appl Environ Microbiol, 2020 Jul 2. PMID 32414791, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.
      Title: Interactions of GMP with Human Glrx3 and with Saccharomyces cerevisiae Grx3 and Grx4 Converge in the Regulation of the Gcn2 Pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GMP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GMP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GMP synthase (glutamine-hydrolyzing)
    NP_013944.1
    • GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      701790..703367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182724.1 → NP_013944.1  TPA: GMP synthase (glutamine-hydrolyzing) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013944.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W042, P38625
      UniProtKB/TrEMBL
      A6ZMS9, B3LMA5, C7GRD4, C8ZF81, G2WKS4, N1P5U5
      Conserved Domains (1) summary
      PRK00074
      Location:9 → 525
      guaA; GMP synthase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38625.4

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