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    KCC4 serine/threonine protein kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850334, updated on 7-Jul-2024

    Summary

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    Gene symbol
    KCC4
    Gene description
    serine/threonine protein kinase
    Primary source
    FungiDB:YCL024W
    Locus tag
    YCL024W
    See related
    SGD:S000000529; AllianceGenome:SGD:S000000529; VEuPathDB:YCL024W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein kinase activity. Involved in budding cell bud growth; mitotic morphogenesis checkpoint signaling; and septin ring assembly. Located in cellular bud neck septin collar and septin ring. Part of incipient cellular bud site. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KCC4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (79162..82275)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene type II nitroreductase Neighboring gene amino acid transporter AGP1 Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast. Asano S, et al. J Biol Chem, 2006 Sep 15. PMID 16861226
    2. Role of the septin ring in the asymmetric localization of proteins at the mother-bud neck in Saccharomyces cerevisiae. Kozubowski L, et al. Mol Biol Cell, 2005 Aug. PMID 15901837, Free PMC Article
    3. The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Okuzaki D, et al. Genes Genet Syst, 2003 Apr. PMID 12773812
    4. Kcc4 associates with septin proteins of Saccharomyces cerevisiae. Okuzaki D, et al. FEBS Lett, 2001 Feb 2. PMID 11165249
    5. Microtubule capture by the cleavage apparatus is required for proper spindle positioning in yeast. Kusch J, et al. Genes Dev, 2002 Jul 1. PMID 12101122, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in budding cell bud growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic morphogenesis checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin collar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase
    NP_009907.2
    • Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      79162..82275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178670.1 → NP_009907.2  TPA: serine/threonine protein kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009907.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ2, P25389, P87005, Q8NKJ8
      UniProtKB/TrEMBL
      C8Z466, N1P667
      Conserved Domains (2) summary
      cd12194
      Location:920 → 1034
      Kcc4p_like_C; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins
      cl21453
      Location:19 → 285
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25389.3

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