TEL2 Tel2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TEL2
Official Full Name: Tel2p
Primary source: SGD:S000003331
Locus tag: YGR099W
See related: AllianceGenome:SGD:S000003331; FungiDB:YGR099W; VEuPathDB:YGR099W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables telomeric DNA binding activity. Involved in protein localization to chromosome and telomere maintenance via telomerase. Located in chromosome, telomeric region. Part of ASTRA complex. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TEL2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (687899..689965)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It has become apparent in the last decade that the stability or maturation of the PIKK family members depends on a molecular chaperone called the Tel2-Tti1-Tti2 (TTT) complex
Title: Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases.
Our findings provide a model in which two different Tel2 pathways promote protein stabilization of Mec1 and Tel1 in budding yeast.
Title: Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast.
present a structural and biochemical analysis of Hsp90-Tah1-Pih1, Hsp90-Spagh, and Pih1D1-Tel2 complexes that reveal a domain in Pih1D1 specific for binding CK2 phosphorylation sites
Title: Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1.
Existence of a novel role for Tel2, namely in transcription, possibly in cooperation with Rvb2 and involving the existence of physical interactions with the Med15/Gal11 Mediator subunit.
Title: Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.
these findings demonstrate separation of function explainable by differential binding of Tel2 to its PIKK substrates Tel1 or Tor1/Tor2 and thus a critical contribution of Tel2 to the interface that links various PIKKs to this chaperone complex.
Title: Saccharomyces cerevisiae Tel2 plays roles in TORC signaling and telomere maintenance that can be mutationally separated.
Tel2 can specifically and differentially regulate the function of individual PIKKs.
Title: Mec1 function in the DNA damage response does not require its interaction with Tel2.
Data show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interaction is specifically required for Tel1 localization to a DNA break and its activation of downstream targets.
Title: Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' cotranslational protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tel2p

NP_011613.3

Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

687899..689965

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181228.3 → NP_011613.3 TPA: Tel2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011613.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUN1, P53038

UniProtKB/TrEMBL

A6ZV81, B3LIC7, C7GWW4

Conserved Domains (1) summary

pfam10193
Location:434 → 546

Telomere_reg-2; Telomere length regulation protein