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    BRR1 Brr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856170, updated on 17-May-2024

    Summary

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    Gene symbol
    BRR1
    Gene description
    Brr1p
    Primary source
    FungiDB:YPR057W
    Locus tag
    YPR057W
    See related
    SGD:S000006261; AllianceGenome:SGD:S000006261; VEuPathDB:YPR057W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables snRNA binding activity. Involved in spliceosomal complex assembly. Part of small nuclear ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BRR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (672471..673496)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene exocyst subunit SEC8 Neighboring gene TFIIH/NER complex subunit TFB4 Neighboring gene organic acid transporter Neighboring gene chorismate mutase ARO7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. Noble SM, et al. EMBO J, 1996 Aug 15. PMID 8861964, Free PMC Article
    2. Mutations in the Saccharomyces cerevisiae kinase Cbk1p lead to a fertility defect that can be suppressed by the absence of Brr1p or Mpt5p (Puf5p), proteins involved in RNA metabolism. Bourens M, et al. Genetics, 2009 Sep. PMID 19546315, Free PMC Article
    3. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Noble SM, et al. Genetics, 1996 May. PMID 8722763, Free PMC Article
    4. Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors. Schwer B, et al. Nucleic Acids Res, 2013 Aug. PMID 23754852, Free PMC Article
    5. Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. Qiu ZR, et al. RNA, 2012 Nov. PMID 23002122, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2.
      Title: Will the circle be unbroken: specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of Gemin2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small nuclear ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small nuclear ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Brr1p
    NP_015382.1
    • snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      672471..673496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184154.1 → NP_015382.1  TPA: Brr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015382.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W463, Q99177
      UniProtKB/TrEMBL
      A0A6A5Q1H3, B3LLB2, B5VTK9, C7GY44, C8ZJ82, N1NWC0
      Conserved Domains (1) summary
      pfam04938
      Location:141 → 337
      SIP1; Survival motor neuron (SMN) interacting protein 1 (SIP1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99177.1

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