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    ARP5 Arp5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855665, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARP5
    Official Full Name
    Arp5p
    Primary source
    SGD:S000005004
    Locus tag
    YNL059C
    See related
    AllianceGenome:SGD:S000005004; FungiDB:YNL059C; VEuPathDB:YNL059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme regulator activity. Involved in nucleosome mobilization. Located in nucleus. Part of Ino80 complex. Orthologous to human ACTR5 (actin related protein 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARP5 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (512668..514935, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA 1-methyladenosine methyltransferase subunit GCD10 Neighboring gene rRNA (cytosine-C5-)-methyltransferase NOP2 Neighboring gene uncharacterized protein Neighboring gene Oca2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near +1 nucleosomes. Yen K, et al. Cell, 2013 Sep 12. PMID 24034248, Free PMC Article
    2. Actin-related proteins (Arps): conformational switches for chromatin-remodeling machines? Boyer LA, et al. Bioessays, 2000 Jul. PMID 10878579
    3. A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function. Hsieh LJ, et al. Mol Cell, 2022 Jun 2. PMID 35597239, Free PMC Article
    4. The Ino80 complex prevents invasion of euchromatin into silent chromatin. Xue Y, et al. Genes Dev, 2015 Feb 15. PMID 25691465, Free PMC Article
    5. INO80C Remodeler Maintains Genomic Stability by Preventing Promiscuous Transcription at Replication Origins. Topal S, et al. Cell Rep, 2020 Sep 8. PMID 32905765, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular non-membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arp5p
    NP_014339.1
    • Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      512668..514935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182898.1 → NP_014339.1  TPA: Arp5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1C0, P53946
      UniProtKB/TrEMBL
      A6ZS20, G2WM45, N1NXK3
      Conserved Domains (3) summary
      COG5277
      Location:33 → 358
      COG5277; Actin-related protein [Cytoskeleton]
      PRK00409
      Location:292 → 428
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      cl17037
      Location:536 → 748
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53946.1

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