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    cbc1 nuclear cap-binding complex large subunit [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542556, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cbc1
    Official Full Name
    nuclear cap-binding complex large subunit
    Primary source
    PomBase:SPAC6G10.07
    Locus tag
    SPOM_SPAC6G10.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cbc1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (3228510..3231398)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene TRAPP complex subunit Trs120 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FAD-dependent amino acid oxidase Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase Idp1 Neighboring gene uncharacterized protein Neighboring gene glucosidase I Gls1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clr4 specificity and catalytic activity beyond H3K9 methylation. Kusevic D, et al. Biochimie, 2017 Apr. PMID 28143796
    2. Conserved protein Pir2(ARS2) mediates gene repression through cryptic introns in lncRNAs. Thillainadesan G, et al. Nat Commun, 2020 May 15. PMID 32415063, Free PMC Article
    3. Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis. Pebernard S, et al. Mol Biol Cell, 2004 Nov. PMID 15331764, Free PMC Article
    4. The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome. Zhou Y, et al. Nat Commun, 2015 May 20. PMID 25989903, Free PMC Article
    5. Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs. Lemieux C, et al. Nucleic Acids Res, 2009 Jun. PMID 19336419, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IC
    Inferred by Curator
    more info
    		  
    enables RNA cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear polyadenylation-dependent CUT catabolic process IC
    Inferred by Curator
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of nuclear cap binding complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear cap-binding complex large subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3228510..3231398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019528.3 → NP_594104.1  nuclear cap-binding complex large subunit [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594104.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14253
      Conserved Domains (3) summary
      pfam02854
      Location:36 → 249
      MIF4G; MIF4G domain
      pfam09088
      Location:309 → 499
      MIF4G_like; MIF4G like
      pfam09090
      Location:517 → 710
      MIF4G_like_2; MIF4G like
    Nucleotide Protein
    Heading Accession and Version

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