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    BIT61 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853388, updated on 11-Sep-2024

    Summary

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    Official Symbol
    BIT61
    Primary source
    SGD:S000003594
    Locus tag
    YJL058C
    See related
    AllianceGenome:SGD:S000003594; FungiDB:YJL058C; VEuPathDB:YJL058C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in establishment or maintenance of actin cytoskeleton polarity; fungal-type cell wall organization; and regulation of cell growth. Located in plasma membrane. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (326242..327873, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene kynurenine--oxoglutarate transaminase Neighboring gene amino acid transporter YHC3 Neighboring gene protein kinase IKS1 Neighboring gene Zap1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Berchtold D, et al. Mol Biol Cell, 2009 Mar. PMID 19144819, Free PMC Article
    2. Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2. Martinez Marshall MN, et al. Mol Biol Cell, 2019 Jun 1. PMID 30969890, Free PMC Article
    3. Methylglyoxal activates the target of rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae. Nomura W, et al. Mol Cell Biol, 2015 Apr. PMID 25624345, Free PMC Article
    4. TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity. Bartlett K, et al. J Biosci, 2015 Jun. PMID 25963258
    5. Target of rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-rapamycin-2 protein 1 (Avo1) in Saccharomyces cerevisiae. Liao HC, et al. J Biol Chem, 2012 Feb 24. PMID 22207764, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of actin cytoskeleton polarity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of cell growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bit61p
    NP_012477.1
    • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p; BIT61 has a paralog, BIT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      326242..327873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181491.1 → NP_012477.1  TPA: Bit61p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWC4, P47041
      UniProtKB/TrEMBL
      A6ZPR5, G2WGV8, N1P0V7
      Conserved Domains (1) summary
      pfam08539
      Location:319 → 480
      HbrB; HbrB-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47041.1

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