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    PHO5 acid phosphatase PHO5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852390, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PHO5
    Official Full Name
    acid phosphatase PHO5
    Primary source
    SGD:S000000297
    Locus tag
    YBR093C
    See related
    AllianceGenome:SGD:S000000297; FungiDB:YBR093C; VEuPathDB:YBR093C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables acid phosphatase activity; nucleoside triphosphate diphosphatase activity; and ribonucleoside triphosphate phosphatase activity. Involved in cellular response to phosphate starvation and phosphate-containing compound metabolic process. Located in fungal-type cell wall. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PHO5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (429548..430951, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Tim12p Neighboring gene acid phosphatase PHO3 Neighboring gene putative tubulin tyrosine ligase Neighboring gene Rxt2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reciprocal regulation of the tandemly duplicated PHO5/PHO3 gene cluster within the acid phosphatase multigene family of Saccharomyces cerevisiae. Tait-Kamradt AG, et al. Mol Cell Biol, 1986 Jun. PMID 3537710, Free PMC Article
    2. An in vitro system recapitulates chromatin remodeling at the PHO5 promoter. Haswell ES, et al. Mol Cell Biol, 1999 Apr. PMID 10082547, Free PMC Article
    3. Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity. Small EC, et al. Proc Natl Acad Sci U S A, 2014 Jun 17. PMID 24889621, Free PMC Article
    4. The yeast PHO5 promoter: from single locus to systems biology of a paradigm for gene regulation through chromatin. Korber P, et al. Nucleic Acids Res, 2014. PMID 25190457, Free PMC Article
    5. Nucleosomal promoter variation generates gene expression noise. Brown CR, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25468975, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A review of the PHO5 promoter as a paradigm for gene regulation through chromatin remodeling.
      Title: The yeast PHO5 promoter: from single locus to systems biology of a paradigm for gene regulation through chromatin.
    2. three histone methylation mutants exhibited more severe growth defects and slower activation of GAL1, SSA3 and PHO5 than those of wild type
      Title: [Effects of histone H3 K4L and K36L mutations on the cell growth and the transcription of GAL1, SSA3 and PHO5 in Saccharomyces cerevisiae].
    3. The results show that remodels the structure of chromatin (RSC) is crucially involved in PHO5 promoter opening.
      Title: The RSC chromatin remodeling complex has a crucial role in the complete remodeler set for yeast PHO5 promoter opening.
    4. we provide evidence that topoisomerases are required to maintain the PHO5 promoter in a superhelical state, which is competent for proper activation.
      Title: DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.
    5. data suggest that Set1-mediated H3K4me suppresses nucleosome remodeling at the PHO5 promoter so as to reduce basal transcription of PHO5 under repressive conditions
      Title: Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter.
    6. auxiliary role for DNA binding competition between Pho4 and histones in PHO5 promoter chromatin remodeling
      Title: In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.
    7. The Mcm1-Fkh2 complex, first shown to transactivate genes within the CLB2 cluster that drive G(2)/M progression, also associated directly at the PHO5 promoter in a cell cycle-dependent manner.
      Title: Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins.
    8. Nap1 regulates transcription of PHO5.
      Title: Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
    9. analysis of complete independence of promoter chromatin opening from downstream PHO5 transcription processes
      Title: Redundancy of chromatin remodeling pathways for the induction of the yeast PHO5 promoter in vivo.
    10. Chromatin diassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.
      Title: Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside triphosphate diphosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables nucleoside triphosphate diphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ribonucleoside triphosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to phosphate starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate-containing compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size HMP PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acid phosphatase PHO5
    NP_009651.3
    • Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      429548..430951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178441.3 → NP_009651.3  TPA: acid phosphatase PHO5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009651.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ94, P00635
      UniProtKB/TrEMBL
      A6ZL40, B3LN58, D3UEI8
      Conserved Domains (1) summary
      pfam00328
      Location:65 → 399
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00635.2

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