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    EGD1 Egd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856070, updated on 28-Oct-2024

    Summary

    Official Symbol
    EGD1
    Official Full Name
    Egd1p
    Primary source
    SGD:S000005958
    Locus tag
    YPL037C
    See related
    AllianceGenome:SGD:S000005958; FungiDB:YPL037C; VEuPathDB:YPL037C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in cotranslational protein targeting to membrane and macroautophagy. Acts upstream of or within mitophagy. Part of nascent polypeptide-associated complex. Orthologous to human BTF3 (basic transcription factor 3) and BTF3L4 (basic transcription factor 3 like 4). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See EGD1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (481428..481901, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Met31p Neighboring gene H(+)-exporting P2-type ATPase PMA2 Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cotranslational protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nascent polypeptide-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nascent polypeptide-associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Egd1p
    NP_015288.1
    • Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting to mitochondria; peripheral component of cytoplasmic ribosomes; regulates Atg32p phosphorylation to promote respiration-induced mitophagy; enhances DNA binding of the Gal4p; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      481428..481901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183851.1NP_015288.1  TPA: Egd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZWL1, D6W3X7, Q02107, Q02642
      UniProtKB/TrEMBL
      B3LL28, C7GU17, C8ZIZ2, G2WPE2, N1NXB6
      Conserved Domains (1) summary
      cd22055
      Location:9125
      NAC_BTF3; basal transcription factor BTF3