MGM101 Mgm101p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: MGM101
Gene description: Mgm101p
Primary source: FungiDB:YJR144W
Locus tag: YJR144W
See related: SGD:S000003905; AllianceGenome:SGD:S000003905
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MGM9
Summary: Enables single-stranded DNA binding activity. Involved in interstrand cross-link repair; mitochondrial genome maintenance; and recombinational repair. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The carboxy terminal-tail of Mgm101, likely displayed on the ring surface, is required for single stranded DNA binding.
Title: A short carboxyl-terminal tail is required for single-stranded DNA binding, higher-order structural organization, and stability of the mitochondrial single-stranded annealing protein Mgm101.
Data indicate that Mgm101p is found in the mitochondrial nucleoid along with enzymes and proteins involved in mtDNA replication.
Title: The N-terminal intrinsically disordered domain of Mgm101p is localized to the mitochondrial nucleoid.
A potential role of Cys-216 and Cys-217 in regulating Mgm101 function and the repair of damaged mtDNA under stress conditions.
Title: A properly configured ring structure is critical for the function of the mitochondrial DNA recombination protein, Mgm101.
Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination
Title: Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination.
a previously identified recessive temperature-sensitive mgm101-1ts mutation was used as a detection system to examine the functionality of Mgm101p
Title: A functional core of the mitochondrial genome maintenance protein Mgm101p in Saccharomyces cerevisiae determined with a temperature-conditional allele.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial genome maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in recombinational repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in recombinational repair	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial chromosome	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_012678.1

Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance