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    hsp104 heat shock protein Hsp104 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540026, updated on 18-Sep-2024

    Summary

    Official Symbol
    hsp104
    Official Full Name
    heat shock protein Hsp104
    Primary source
    PomBase:SPBC16D10.08c
    Locus tag
    SPOM_SPBC16D10.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

    See hsp104 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3612265..3615269, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene histone deacetylase, Sirtuin family, NAD-dependent Sir2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA polymerase delta processivity factor

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent protein disaggregase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables misfolded protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cellular heat acclimation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein refolding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein refolding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein unfolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein unfolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleolar peripheral inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in protein aggregate center IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3612265..3615269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022424.3NP_596503.1  heat shock protein Hsp104 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596503.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94641
      Conserved Domains (7) summary
      cd00009
      Location:184345
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      TIGR03346
      Location:6874
      chaperone_ClpB; ATP-dependent chaperone ClpB
      pfam02861
      Location:98148
      Clp_N; Clp amino terminal domain, pathogenicity island component
      pfam07724
      Location:614776
      AAA_2; AAA domain (Cdc48 subfamily)
      pfam10431
      Location:785867
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      cl02376
      Location:374456
      DUF2390; Protein of unknown function (DUF2390)
      cl23765
      Location:437492
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits