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    AAD14 putative aryl-alcohol dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855385, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAD14
    Official Full Name
    putative aryl-alcohol dehydrogenase
    Primary source
    SGD:S000005275
    Locus tag
    YNL331C
    See related
    AllianceGenome:SGD:S000005275; FungiDB:YNL331C; VEuPathDB:YNL331C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aryl-alcohol dehydrogenase (NADP+) activity. Predicted to be involved in cellular aldehyde metabolic process. Orthologous to several human genes including AKR7A2 (aldo-keto reductase family 7 member A2) and AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AAD14 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (16118..17248, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene pyridoxine biosynthesis protein SNZ2 Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene histone deacetylase RPD3 Neighboring gene AAA family ATPase peroxin 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae. Yang DD, et al. Appl Environ Microbiol, 2018 Jan 1. PMID 29079624, Free PMC Article
    2. Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real. Delneri D, et al. Genetics, 1999 Dec. PMID 10581269, Free PMC Article
    3. Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain. Delneri D, et al. Yeast, 1999 Nov. PMID 10572264
    4. Functional analysis of eight open reading frames on chromosomes XII and XIV of Saccharomyces cerevisiae. Ahmed Khan S, et al. Yeast, 2000 Dec. PMID 11113969
    5. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna IA, et al. J Org Chem, 2005 Jan 7. PMID 15624945

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aryl-alcohol dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl-alcohol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative aryl-alcohol dehydrogenase
    NP_014068.1
    • Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      16118..17248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183169.1 → NP_014068.1  TPA: putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0L6, P42884
      UniProtKB/TrEMBL
      A6ZSF1, G2WLE0, N1NWE0
      Conserved Domains (1) summary
      cd19147
      Location:20 → 338
      AKR_AKR9A3_9B1-4; Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42884.1

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