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    KTR5 putative mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855703, updated on 17-May-2024

    Summary

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    Gene symbol
    KTR5
    Gene description
    putative mannosyltransferase
    Primary source
    FungiDB:YNL029C
    Locus tag
    YNL029C
    See related
    SGD:S000004974; AllianceGenome:SGD:S000004974; VEuPathDB:YNL029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in cell wall mannoprotein biosynthetic process; mannosylation; and protein N-linked glycosylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KTR5 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (577205..578773, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene histone H3 Neighboring gene histone H4 Neighboring gene DNA-binding transcription factor CRZ1 Neighboring gene SAM complex subunit SAM50

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways. Hernández NV, et al. Res Microbiol, 2017 Oct. PMID 28774774
    2. Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Lussier M, et al. Yeast, 1997 Mar 15. PMID 9090056
    3. Acetylation in histone H3 globular domain regulates gene expression in yeast. Xu F, et al. Cell, 2005 May 6. PMID 15882620
    4. The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Kochan DZ, et al. J Cell Sci, 2021 Aug 1. PMID 34350963, Free PMC Article
    5. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KTR4, KTR5 and KTR7 have a redundant activity in the S. cerevisiae N-linked glycosylation pathway, but KTR4 plays a major role in O-linked glycan synthesis.
      Title: Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mannosylation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mannosyltransferase
    NP_014369.3
    • Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      577205..578773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182868.3 → NP_014369.3  TPA: putative mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014369.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1F0, P53966
      UniProtKB/TrEMBL
      A0A8H4F999, C7GWP6
      Conserved Domains (1) summary
      COG5020
      Location:6 → 499
      KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53966.1

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