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    Plekho2 pleckstrin homology domain containing, family O member 2 [ Mus musculus (house mouse) ]

    Gene ID: 102595, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Plekho2provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family O member 2provided by MGI
    Primary source
    MGI:MGI:2143132
    See related
    Ensembl:ENSMUSG00000050721 AllianceGenome:MGI:2143132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plekhq1
    Summary
    Acts upstream of or within macrophage apoptotic process. Orthologous to human PLEKHO2 (pleckstrin homology domain containing O2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 18.7), adrenal adult (RPKM 15.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekho2 in Genome Data Viewer
    Location:
    9 C; 9 35.38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65459859..65487369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65552577..65580087, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SPG21, maspardin Neighboring gene ankyrin repeat and death domain containing 1A Neighboring gene STARR-seq mESC enhancer starr_24454 Neighboring gene predicted gene, 17749 Neighboring gene STARR-positive B cell enhancer ABC_E2896 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65389334-65389517 Neighboring gene STARR-positive B cell enhancer ABC_E2897 Neighboring gene STARR-positive B cell enhancer ABC_E9331 Neighboring gene STARR-seq mESC enhancer starr_24458 Neighboring gene STARR-positive B cell enhancer ABC_E892 Neighboring gene STARR-positive B cell enhancer ABC_E2898 Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene predicted pseudogene 10144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLEKHO2 inhibits TNFα-induced cell death by suppressing RIPK1 activation. Zhou C, et al. Cell Death Dis, 2021 Jul 16. PMID 34272357, Free PMC Article
    2. PLEKHO2 is essential for M-CSF-dependent macrophage survival. Zhang P, et al. Cell Signal, 2017 Sep. PMID 28627369
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30448

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in macrophage apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family O member 2
    Names
    PH domain-containing family O member 2
    PH domain-containing family Q member 1
    PH domain-containing protein homolog
    pleckstrin homology domain containing, family Q member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153119.3 → NP_694759.1  pleckstrin homology domain-containing family O member 2

      See identical proteins and their annotated locations for NP_694759.1

      Status: VALIDATED

      Source sequence(s)
      AC135108, AK028069, AK158288, BY193678
      Consensus CDS
      CCDS23294.1
      UniProtKB/Swiss-Prot
      Q3TCY2, Q3U4R2, Q8C1F2, Q8K124, Q8R140
      Related
      ENSMUSP00000063677.8, ENSMUST00000068944.9
      Conserved Domains (2) summary
      cd13317
      Location:15 → 115
      PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
      pfam00169
      Location:21 → 119
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65459859..65487369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313067.3 → XP_017168556.1  pleckstrin homology domain-containing family O member 2 isoform X2

    2. XM_017313066.2 → XP_017168555.1  pleckstrin homology domain-containing family O member 2 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:138 → 399
      PHA03247; large tegument protein UL36; Provisional
      cl17171
      Location:83 → 104
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K124.1 GenPept UniProtKB/Swiss-Prot:Q8K124

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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