U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GRB10 growth factor receptor bound protein 10 [ Homo sapiens (human) ]

    Gene ID: 2887, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GRB10provided by HGNC
    Official Full Name
    growth factor receptor bound protein 10provided by HGNC
    Primary source
    HGNC:HGNC:4564
    See related
    Ensembl:ENSG00000106070 MIM:601523; AllianceGenome:HGNC:4564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSS; IRBP; MEG1; GRB-IR; Grb-10
    Summary
    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GRB10 in Genome Data Viewer
    Location:
    7p12.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (50590068..50793453, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (50751214..50954643, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50657765..50861150, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:50514049-50515248 Neighboring gene Sharpr-MPRA regulatory region 9826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18183 Neighboring gene fidgetin like 1 Neighboring gene VISTA enhancer hs2059 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr7:50569579-50570080 and GRCh37_chr7:50570081-50570580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50581285-50581919 Neighboring gene dopa decarboxylase Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_99424 and experimental_99425 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:50598907-50600106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:50602470-50603669 Neighboring gene DDC antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:50637965-50638490 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99443 Neighboring gene uncharacterized LOC124901632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50720584-50721214 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99457 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50736937-50737438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50737439-50737938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50782907-50783422 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_99483 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50836560-50837139 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:50837140-50837720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50875755-50876262 Neighboring gene Sharpr-MPRA regulatory region 14531 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:50894096-50895295 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:50905976-50907175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50920730-50921230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50921231-50921731 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50935547-50936047 Neighboring gene ribosomal protein L39 pseudogene 23 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:50954893-50955392 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50966118-50966911 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50966912-50967704 Neighboring gene MPRA-validated peak6518 silencer Neighboring gene small nucleolar RNA SNORA4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Up-regulation of growth factor receptor-bound protein 10 in cervical squamous cell carcinoma. Okino K, et al. Oncol Rep, 2005 Jun. PMID 15870923
    2. Proproliferative function of adaptor protein GRB10 in prostate carcinoma. Khan MI, et al. FASEB J, 2019 Mar. PMID 30379590, Free PMC Article
    3. Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer. Hao J, et al. Eur Urol, 2018 Jun. PMID 29544736
    4. High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells. Li H, et al. Oncotarget, 2017 Jul 18. PMID 28476045, Free PMC Article
    5. Placental expression of the insulin receptor binding protein GRB10: Relation to human fetoplacental growth and fetal gender. Mukhopadhyay A, et al. Placenta, 2015 Nov. PMID 26390806

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRB10 is a novel factor associated with gastric cancer proliferation and prognosis.
      Title: GRB10 is a novel factor associated with gastric cancer proliferation and prognosis.
    2. Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis.
      Title: Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis.
    3. GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells.
      Title: GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells.
    4. inhibition of mTORC1 with rapamycin blocked Grb10 Ser476 phosphorylation and repressed a negative-feedback loop on PI3K/Akt signaling that increased myotube responsiveness to insulin
      Title: Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells.
    5. results suggest that GRB10 acts as a major downstream effector of PI3K and has tumor-promoting effects in prostate cancer
      Title: Proproliferative function of adaptor protein GRB10 in prostate carcinoma.
    6. Using state-of-the-art patient-derived hormone-naive prostate cancer xenograft models,we found and validated the growth factor receptor bound protein 10 gene as a driver of CRPC.
      Title: Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer.
    7. Through syngeneic comparison, our study identifies for the first time that Grb10 is associated with the pluripotency state in nuclear transfer embryonic stem cells.
      Title: High throughput sequencing identifies an imprinted gene, Grb10, associated with the pluripotency state in nuclear transfer embryonic stem cells.
    8. Study found FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset
      Title: FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset.
    9. Data suggest that GRB10 and GRB14 are both Ca2+-dependent CaM-binding proteins; more than one CaM-binding site and/or accessory CaM-binding sites appear to exist in GRB10 and GRB14, as compared to a single one present in GRB7. (GRB10 = growth factor receptor-bound protein 10; GRB14 = growth factor receptor-bound protein 14; CaM = calmodulin; GRB7 = growth factor receptor-bound protein 7)
      Title: The adaptors Grb10 and Grb14 are calmodulin-binding proteins.
    10. GRB10 may regulate degradation of the IL-4 receptor-signaling complex through interactions with NEDD4.2.
      Title: The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-03-23)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-03-23)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.
    EBI GWAS Catalog
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
    EBI GWAS Catalog
    Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0207

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor complex adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of D-glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to insulin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    growth factor receptor-bound protein 10
    Names
    GRB10 adapter protein
    GRB10 adaptor protein
    insulin receptor-binding protein Grb-IR
    maternally expressed gene 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012305.2 RefSeqGene

      Range
      5010..208395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1032

    mRNA and Protein(s)

    1. NM_001001549.3 → NP_001001549.1  growth factor receptor-bound protein 10 isoform b

      See identical proteins and their annotated locations for NP_001001549.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as hGrb10alpha, lacks an in-frame segment in the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AC005153, AC080092
      Consensus CDS
      CCDS47586.1
      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000349818.5, ENST00000357271.9
      Conserved Domains (4) summary
      cd01787
      Location:166 → 248
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:441 → 548
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:283 → 362
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:380 → 421
      BPS; BPS (Between PH and SH2)

    2. NM_001001550.3 → NP_001001550.1  growth factor receptor-bound protein 10 isoform c

      See identical proteins and their annotated locations for NP_001001550.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as hGrb10beta, differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 4, 6, and 7.
      Source sequence(s)
      AC005153, AC080092
      Consensus CDS
      CCDS43583.1
      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000381790.2, ENST00000398810.6
      Conserved Domains (4) summary
      cd10415
      Location:429 → 536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108 → 199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368 → 409
      BPS; BPS (Between PH and SH2)

    3. NM_001001555.3 → NP_001001555.1  growth factor receptor-bound protein 10 isoform c

      See identical proteins and their annotated locations for NP_001001555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 3, 4, 6, and 7.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS43583.1
      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000338543.3, ENST00000335866.7
      Conserved Domains (4) summary
      cd10415
      Location:429 → 536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108 → 199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368 → 409
      BPS; BPS (Between PH and SH2)

    4. NM_001350814.2 → NP_001337743.1  growth factor receptor-bound protein 10 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS43582.1
      UniProtKB/Swiss-Prot
      A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q13322, Q92606, Q92907, Q92948
      Related
      ENSP00000385770.1, ENST00000401949.6
      Conserved Domains (4) summary
      cd01787
      Location:166 → 248
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:487 → 594
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:286 → 408
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:426 → 467
      BPS; BPS (Between PH and SH2)

    5. NM_001350815.2 → NP_001337744.1  growth factor receptor-bound protein 10 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform d.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS87504.1
      UniProtKB/TrEMBL
      A0A2R8YCL1
      Related
      ENSP00000493728.1, ENST00000644879.1
      Conserved Domains (4) summary
      cd01787
      Location:204 → 286
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:525 → 632
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:324 → 446
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:464 → 505
      BPS; BPS (Between PH and SH2)

    6. NM_001350816.3 → NP_001337745.2  growth factor receptor-bound protein 10 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 4, and 7, encodes isoform c.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS43583.1
      Conserved Domains (4) summary
      cd10415
      Location:429 → 536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108 → 199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368 → 409
      BPS; BPS (Between PH and SH2)

    7. NM_001371008.1 → NP_001357937.1  growth factor receptor-bound protein 10 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS43583.1
      Related
      ENSP00000495341.2, ENST00000645075.2
      Conserved Domains (4) summary
      cd10415
      Location:429 → 536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108 → 199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368 → 409
      BPS; BPS (Between PH and SH2)

    8. NM_001371009.1 → NP_001357938.1  growth factor receptor-bound protein 10 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes the longest isoform (f).
      Source sequence(s)
      AC004920, AC005153, AC080092
      Conserved Domains (3) summary
      cd10415
      Location:536 → 643
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:335 → 457
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:215 → 306
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      50590068..50793453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012061.3 → XP_016867550.1  growth factor receptor-bound protein 10 isoform X11

      Conserved Domains (4) summary
      cd01787
      Location:154 → 235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474 → 581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273 → 395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413 → 454
      BPS; BPS (Between PH and SH2)

    2. XM_047420243.1 → XP_047276199.1  growth factor receptor-bound protein 10 isoform X10

    3. XM_047420233.1 → XP_047276189.1  growth factor receptor-bound protein 10 isoform X6

    4. XM_047420241.1 → XP_047276197.1  growth factor receptor-bound protein 10 isoform X8

      UniProtKB/Swiss-Prot
      A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q13322, Q92606, Q92907, Q92948
      Related
      ENSP00000381793.2, ENST00000398812.6

    5. XM_017012034.2 → XP_016867523.1  growth factor receptor-bound protein 10 isoform X5

    6. XM_047420252.1 → XP_047276208.1  growth factor receptor-bound protein 10 isoform X7

    7. XM_047420244.1 → XP_047276200.1  growth factor receptor-bound protein 10 isoform X10

    8. XM_047420240.1 → XP_047276196.1  growth factor receptor-bound protein 10 isoform X6

    9. XM_024446726.2 → XP_024302494.1  growth factor receptor-bound protein 10 isoform X3

      Conserved Domains (4) summary
      cd01787
      Location:250 → 331
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:570 → 677
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:369 → 491
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:509 → 550
      BPS; BPS (Between PH and SH2)

    10. XM_017012030.3 → XP_016867519.1  growth factor receptor-bound protein 10 isoform X2

    11. XM_017012031.3 → XP_016867520.1  growth factor receptor-bound protein 10 isoform X4

    12. XM_017012029.3 → XP_016867518.1  growth factor receptor-bound protein 10 isoform X1

    13. XM_047420253.1 → XP_047276209.1  growth factor receptor-bound protein 10 isoform X7

    14. XM_047420254.1 → XP_047276210.1  growth factor receptor-bound protein 10 isoform X7

    15. XM_047420255.1 → XP_047276211.1  growth factor receptor-bound protein 10 isoform X7

    16. XM_047420238.1 → XP_047276194.1  growth factor receptor-bound protein 10 isoform X6

    17. XM_047420232.1 → XP_047276188.1  growth factor receptor-bound protein 10 isoform X5

    18. XM_047420250.1 → XP_047276206.1  growth factor receptor-bound protein 10 isoform X11

    19. XM_024446729.2 → XP_024302497.1  growth factor receptor-bound protein 10 isoform X11

      Conserved Domains (4) summary
      cd01787
      Location:154 → 235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474 → 581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273 → 395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413 → 454
      BPS; BPS (Between PH and SH2)

    20. XM_047420249.1 → XP_047276205.1  growth factor receptor-bound protein 10 isoform X11

    21. XM_047420247.1 → XP_047276203.1  growth factor receptor-bound protein 10 isoform X11

    22. XM_047420236.1 → XP_047276192.1  growth factor receptor-bound protein 10 isoform X6

    23. XM_047420248.1 → XP_047276204.1  growth factor receptor-bound protein 10 isoform X11

    24. XM_047420246.1 → XP_047276202.1  growth factor receptor-bound protein 10 isoform X11

    25. XM_047420235.1 → XP_047276191.1  growth factor receptor-bound protein 10 isoform X6

    26. XM_047420234.1 → XP_047276190.1  growth factor receptor-bound protein 10 isoform X6

    27. XM_047420245.1 → XP_047276201.1  growth factor receptor-bound protein 10 isoform X11

    28. XM_047420251.1 → XP_047276207.1  growth factor receptor-bound protein 10 isoform X11

    29. XM_047420237.1 → XP_047276193.1  growth factor receptor-bound protein 10 isoform X6

    30. XM_017012058.1 → XP_016867547.1  growth factor receptor-bound protein 10 isoform X11

      Conserved Domains (4) summary
      cd01787
      Location:154 → 235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474 → 581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273 → 395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413 → 454
      BPS; BPS (Between PH and SH2)

    31. XM_017012062.3 → XP_016867551.1  growth factor receptor-bound protein 10 isoform X11

      Conserved Domains (4) summary
      cd01787
      Location:154 → 235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474 → 581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273 → 395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413 → 454
      BPS; BPS (Between PH and SH2)

    32. XM_017012045.1 → XP_016867534.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000385189.1, ENST00000402578.5
      Conserved Domains (4) summary
      cd10415
      Location:429 → 536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228 → 350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108 → 199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368 → 409
      BPS; BPS (Between PH and SH2)

    33. XM_047420242.1 → XP_047276198.1  growth factor receptor-bound protein 10 isoform X9

    34. XM_047420256.1 → XP_047276212.1  growth factor receptor-bound protein 10 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      50751214..50954643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357968.1 → XP_054213943.1  growth factor receptor-bound protein 10 isoform X11

    2. XM_054357966.1 → XP_054213941.1  growth factor receptor-bound protein 10 isoform X10

    3. XM_054357957.1 → XP_054213932.1  growth factor receptor-bound protein 10 isoform X6

    4. XM_054357964.1 → XP_054213939.1  growth factor receptor-bound protein 10 isoform X8

      UniProtKB/Swiss-Prot
      A4D258, A7VJ95, A8K0E6, D3DVM9, O00427, O00701, O75222, Q13322, Q92606, Q92907, Q92948

    5. XM_054357956.1 → XP_054213931.1  growth factor receptor-bound protein 10 isoform X5

    6. XM_054357979.1 → XP_054213954.1  growth factor receptor-bound protein 10 isoform X7

    7. XM_054357953.1 → XP_054213928.1  growth factor receptor-bound protein 10 isoform X3

    8. XM_054357967.1 → XP_054213942.1  growth factor receptor-bound protein 10 isoform X10

    9. XM_054357952.1 → XP_054213927.1  growth factor receptor-bound protein 10 isoform X2

    10. XM_054357954.1 → XP_054213929.1  growth factor receptor-bound protein 10 isoform X4

    11. XM_054357951.1 → XP_054213926.1  growth factor receptor-bound protein 10 isoform X1

    12. XM_054357980.1 → XP_054213955.1  growth factor receptor-bound protein 10 isoform X7

    13. XM_054357981.1 → XP_054213956.1  growth factor receptor-bound protein 10 isoform X7

    14. XM_054357962.1 → XP_054213937.1  growth factor receptor-bound protein 10 isoform X6

    15. XM_054357955.1 → XP_054213930.1  growth factor receptor-bound protein 10 isoform X5

    16. XM_054357976.1 → XP_054213951.1  growth factor receptor-bound protein 10 isoform X11

    17. XM_054357973.1 → XP_054213948.1  growth factor receptor-bound protein 10 isoform X11

    18. XM_054357975.1 → XP_054213950.1  growth factor receptor-bound protein 10 isoform X11

    19. XM_054357971.1 → XP_054213946.1  growth factor receptor-bound protein 10 isoform X11

    20. XM_054357960.1 → XP_054213935.1  growth factor receptor-bound protein 10 isoform X6

    21. XM_054357974.1 → XP_054213949.1  growth factor receptor-bound protein 10 isoform X11

    22. XM_054357970.1 → XP_054213945.1  growth factor receptor-bound protein 10 isoform X11

    23. XM_054357959.1 → XP_054213934.1  growth factor receptor-bound protein 10 isoform X6

    24. XM_054357958.1 → XP_054213933.1  growth factor receptor-bound protein 10 isoform X6

    25. XM_054357969.1 → XP_054213944.1  growth factor receptor-bound protein 10 isoform X11

    26. XM_054357977.1 → XP_054213952.1  growth factor receptor-bound protein 10 isoform X11

    27. XM_054357961.1 → XP_054213936.1  growth factor receptor-bound protein 10 isoform X6

    28. XM_054357972.1 → XP_054213947.1  growth factor receptor-bound protein 10 isoform X11

    29. XM_054357978.1 → XP_054213953.1  growth factor receptor-bound protein 10 isoform X11

    30. XM_054357963.1 → XP_054213938.1  growth factor receptor-bound protein 10 isoform X7

    31. XM_054357965.1 → XP_054213940.1  growth factor receptor-bound protein 10 isoform X9

    32. XM_054357982.1 → XP_054213957.1  growth factor receptor-bound protein 10 isoform X12

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005311.4: Suppressed sequence

      Description
      NM_005311.4: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13322.2 GenPept UniProtKB/Swiss-Prot:Q13322

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous