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    Rps6ka3 ribosomal protein S6 kinase A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501560, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Rps6ka3provided by RGD
    Official Full Name
    ribosomal protein S6 kinase A3provided by RGD
    Primary source
    RGD:1563860
    See related
    EnsemblRapid:ENSRNOG00000006632 AllianceGenome:RGD:1563860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563860
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein kinase binding activity; and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including TORC1 signaling; response to lipopolysaccharide; and toll-like receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 164.9), Muscle (RPKM 141.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps6ka3 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (39325926..39432017, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (35517306..35623296, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (37469736..37576055)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 2 Neighboring gene eukaryotic translation initiation factor 1A, X-linked Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene uncharacterized LOC103690826

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. Merienne K, et al. Nat Genet, 1999 May. PMID 10319851
    2. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Trivier E, et al. Nature, 1996 Dec 12. PMID 8955270
    3. Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase. Chrestensen CA, et al. J Biol Chem, 2002 Aug 2. PMID 12016217
    4. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Zaru R, et al. Nat Immunol, 2007 Nov. PMID 17906627
    5. Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Chen J, et al. Exp Neurol, 2008 Jun. PMID 18402937, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase alpha-3
    Names
    ribosomal protein S6 kinase polypeptide 3
    NP_001178933.1
    XP_006256985.1
    XP_008771414.1
    XP_017457618.1
    XP_038955902.1
    XP_038955904.1
    XP_038955905.1
    XP_038955906.1
    XP_063136319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192004.3 → NP_001178933.1  ribosomal protein S6 kinase alpha-3

      See identical proteins and their annotated locations for NP_001178933.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6G9P7, A6IPN3, D3Z8E0
      Related
      ENSRNOP00000008938.5, ENSRNOT00000008938.8
      Conserved Domains (2) summary
      cd05582
      Location:72 → 388
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:402 → 740
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      39325926..39432017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280249.1 → XP_063136319.1  ribosomal protein S6 kinase alpha-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AR08
      Related
      ENSRNOP00000096596.1, ENSRNOT00000110641.2

    2. XM_017602129.3 → XP_017457618.1  ribosomal protein S6 kinase alpha-3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAF4

    3. XM_039099976.2 → XP_038955904.1  ribosomal protein S6 kinase alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAF4
      Conserved Domains (2) summary
      cd05582
      Location:44 → 360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374 → 712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    4. XM_039099978.2 → XP_038955906.1  ribosomal protein S6 kinase alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAF4
      Conserved Domains (2) summary
      cd05582
      Location:44 → 360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374 → 712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    5. XM_039099974.2 → XP_038955902.1  ribosomal protein S6 kinase alpha-3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAF4, A0A8I6AWX9
      Related
      ENSRNOP00000109534.1, ENSRNOT00000171010.1
      Conserved Domains (2) summary
      cd05582
      Location:50 → 366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380 → 718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    6. XM_039099977.2 → XP_038955905.1  ribosomal protein S6 kinase alpha-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAF4
      Conserved Domains (2) summary
      cd05582
      Location:44 → 360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374 → 712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    7. XM_008773192.4 → XP_008771414.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_008771414.1

      UniProtKB/TrEMBL
      A0A8I6AAF4
      Related
      ENSRNOP00000088908.2, ENSRNOT00000105976.2
      Conserved Domains (2) summary
      cd05582
      Location:44 → 360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374 → 712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    8. XM_006256923.5 → XP_006256985.1  ribosomal protein S6 kinase alpha-3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNU1, A0A8I6AAF4
      Related
      ENSRNOP00000079976.1, ENSRNOT00000094638.2
      Conserved Domains (4) summary
      smart00220
      Location:39 → 298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:43 → 359
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:373 → 711
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:393 → 650
      Pkinase; Protein kinase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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