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    Coro6 coronin 6 [ Mus musculus (house mouse) ]

    Gene ID: 216961, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Coro6provided by MGI
    Official Full Name
    coronin 6provided by MGI
    Primary source
    MGI:MGI:2183448
    See related
    Ensembl:ENSMUSG00000020836 AllianceGenome:MGI:2183448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. Is expressed in bladder; heart; intestine; and skeletal muscle. Orthologous to human CORO6 (coronin 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in heart adult (RPKM 120.1), cortex adult (RPKM 32.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coro6 in Genome Data Viewer
    Location:
    11 B5; 11 46.58 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77353149..77361310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77462321..77470484)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 2 Neighboring gene heat shock protein 1, alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_30053 Neighboring gene 60S ribosomal protein L35-like Neighboring gene VISTA enhancer mm146 Neighboring gene STARR-positive B cell enhancer ABC_E5248 Neighboring gene STARR-seq mESC enhancer starr_30055 Neighboring gene microRNA mir-12181 Neighboring gene ankyrin repeat domain 13b Neighboring gene STARR-seq mESC enhancer starr_30056 Neighboring gene GIT ArfGAP 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton. Chen Y, et al. J Neurosci, 2014 Feb 12. PMID 24523531, Free PMC Article
    2. RBM24 is a major regulator of muscle-specific alternative splicing. Yang J, et al. Dev Cell, 2014 Oct 13. PMID 25313962
    3. Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function. de Groot NE, et al. Sci Rep, 2020 May 6. PMID 32376900, Free PMC Article
    4. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Kannan M, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078390, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction
      Title: Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coronin-6
    Names
    clipin E
    coronin 6/clipin E type D
    coronin, actin binding protein 6
    coronin-like protein E

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368670.1 → NP_001355599.1  coronin-6 isoform D

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Consensus CDS
      CCDS88194.1
      UniProtKB/TrEMBL
      B9EIZ7
      Related
      ENSMUSP00000056862.6, ENSMUST00000052515.12
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_139128.2 → NP_624354.1  coronin-6 isoform A

      See identical proteins and their annotated locations for NP_624354.1

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Consensus CDS
      CCDS25077.1
      UniProtKB/Swiss-Prot
      Q3TZ14, Q5F262, Q5F263, Q5F264, Q5F265, Q920M3, Q920M4, Q920M5
      Related
      ENSMUSP00000021190.3, ENSMUST00000021190.9
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_139129.2 → NP_624355.1  coronin-6 isoform C

      See identical proteins and their annotated locations for NP_624355.1

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Consensus CDS
      CCDS25078.1
      UniProtKB/Swiss-Prot
      Q920M5
      Related
      ENSMUSP00000078703.3, ENSMUST00000079770.3
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 425
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_139130.3 → NP_624356.1  coronin-6 isoform B

      See identical proteins and their annotated locations for NP_624356.1

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Consensus CDS
      CCDS25079.1
      UniProtKB/Swiss-Prot
      Q920M5
      Related
      ENSMUSP00000104028.3, ENSMUST00000108391.9
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_160865.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL607072

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77353149..77361310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532940.3 → XP_006533003.1  coronin-6 isoform X1

      See identical proteins and their annotated locations for XP_006533003.1

      UniProtKB/Swiss-Prot
      Q920M5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006532938.4 → XP_006533001.1  coronin-6 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006532945.4 → XP_006533008.1  coronin-6 isoform X4

      See identical proteins and their annotated locations for XP_006533008.1

      UniProtKB/Swiss-Prot
      Q3TZ14, Q5F262, Q5F263, Q5F264, Q5F265, Q920M3, Q920M4, Q920M5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_036156578.1 → XP_036012471.1  coronin-6 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_006532944.3 → XP_006533007.1  coronin-6 isoform X3

      See identical proteins and their annotated locations for XP_006533007.1

      UniProtKB/Swiss-Prot
      Q920M5
      Related
      ENSMUSP00000099551.2, ENSMUST00000102493.8
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_017314462.3 → XP_017169951.2  coronin-6 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_006532941.3 → XP_006533004.1  coronin-6 isoform X1

      See identical proteins and their annotated locations for XP_006533004.1

      UniProtKB/Swiss-Prot
      Q920M5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_006532942.3 → XP_006533005.1  coronin-6 isoform X1

      See identical proteins and their annotated locations for XP_006533005.1

      UniProtKB/Swiss-Prot
      Q920M5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_017314461.3 → XP_017169950.1  coronin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q920M5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_006532946.3 → XP_006533009.1  coronin-6 isoform X5

      See identical proteins and their annotated locations for XP_006533009.1

      UniProtKB/TrEMBL
      B9EIZ7
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 426
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_006532947.4 → XP_006533010.1  coronin-6 isoform X6

      See identical proteins and their annotated locations for XP_006533010.1

      UniProtKB/Swiss-Prot
      Q920M5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 425
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001779955.3 RNA Sequence

    2. XR_388405.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920M5.1 GenPept UniProtKB/Swiss-Prot:Q920M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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