KMT5B lysine methyltransferase 5B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KMT5Bprovided by HGNC
Official Full Name: lysine methyltransferase 5Bprovided by HGNC
Primary source: HGNC:HGNC:24283
See related: Ensembl:ENSG00000110066 MIM:610881; AllianceGenome:HGNC:24283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CGI85; MRD51; CGI-85; SUV420H1
Summary: This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in thyroid (RPKM 12.1), endometrium (RPKM 8.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (68154863..68213648, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (68158479..68217261, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (67922330..67981115, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.
Title: Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.
Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
Title: Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Title: Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis.
Title: Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis.
Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease.
Title: Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease.
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Title: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Title: Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
SUV420H1 is a protein lysine methyltransferase that introduces di- and trimethylation of H4K20 and is frequently mutated in human cancers. Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
Title: Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
epsilon-globin expression is regulated by SUV4-20h1.
Title: ε-globin expression is regulated by SUV4-20h1.
Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes.
Title: Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability, autosomal dominant 51 MedGen: C4540474 OMIM: 617788 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2023-06-13) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2023-06-13) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of suppressor of variegation 4-20 homolog 1 (SUV420H1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-89329 (e-PCR)
- UniSTS:104964

RH94294 (e-PCR)
- UniSTS:91171

G32461 (e-PCR)
- UniSTS:117046

D11S2264E (e-PCR)
- UniSTS:37691

SHGC-31912 (e-PCR)
- UniSTS:25155

A009D47 (e-PCR)
- UniSTS:74619

RH17770 (e-PCR)
- UniSTS:49019

SHGC-154888 (e-PCR)
- UniSTS:182447

G20496 (e-PCR)
- UniSTS:2743

A005U01 (e-PCR)
- UniSTS:2744

WI-14303 (e-PCR)
- UniSTS:38360

D11S3845 (e-PCR)
- UniSTS:153075

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H4 methyltransferase activity	TAS Traceable Author Statement more info
enables histone H4K20 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K20 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K20 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H4K20 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20me methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of isotype switching	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase KMT5B

Names: [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine (K)-specific methyltransferase 5B; lysine N-methyltransferase 5B; lysine-specific methyltransferase 5B; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1

NP_001287836.1

EC 2.1.1.361

EC 2.1.1.362

NP_001287837.1

EC 2.1.1.361

EC 2.1.1.362

NP_001287838.1

EC 2.1.1.361

EC 2.1.1.362

NP_001350495.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356353.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356354.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356355.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356356.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356357.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356358.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356359.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356360.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356361.1

EC 2.1.1.361

EC 2.1.1.362

NP_001356362.1

EC 2.1.1.361

EC 2.1.1.362

NP_057112.3

EC 2.1.1.361

EC 2.1.1.362

NP_060105.3

EC 2.1.1.361

EC 2.1.1.362

XP_005274092.2

EC 2.1.1.361

EC 2.1.1.362

XP_005274093.2

EC 2.1.1.361

EC 2.1.1.362

XP_006718644.1

EC 2.1.1.361

EC 2.1.1.362

XP_011543394.1

EC 2.1.1.361

EC 2.1.1.362

XP_024304338.1

EC 2.1.1.361

EC 2.1.1.362

XP_047283027.1

EC 2.1.1.361

EC 2.1.1.362

XP_047283028.1

EC 2.1.1.361

EC 2.1.1.362

XP_047283029.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225022.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225023.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225024.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225025.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225026.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225027.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225028.1

EC 2.1.1.361

EC 2.1.1.362

XP_054225029.1

EC 2.1.1.361

EC 2.1.1.362

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052873.1 RefSeqGene

Range

5477..63910

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300907.1 → NP_001287836.1 histone-lysine N-methyltransferase KMT5B isoform 3

See identical proteins and their annotated locations for NP_001287836.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AP002992, BC108304

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001300908.2 → NP_001287837.1 histone-lysine N-methyltransferase KMT5B isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate first exon and an alternate splice junction at the 5' end of an exon, and uses a downstream start codon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK314336, AP002992, CR997801

Conserved Domains (1) summary

pfam00856
Location:21 → 68

SET; SET domain
NM_001300909.2 → NP_001287838.1 histone-lysine N-methyltransferase KMT5B isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate first exon, lacks an alternate in-frame exon, and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.

Source sequence(s)

AK299201, AP002992, BC002522, CR997801, KC877427

Consensus CDS

CCDS76444.1

UniProtKB/TrEMBL

B7WNX0, B7Z5N2

Related

ENSP00000384724.2, ENST00000402185.6

Conserved Domains (1) summary

smart00317
Location:180 → 291

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001363566.2 → NP_001350495.1 histone-lysine N-methyltransferase KMT5B isoform 6

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS86221.1

UniProtKB/TrEMBL

B5MCB3, B7Z5N2

Related

ENSP00000385005.1, ENST00000402789.5

Conserved Domains (1) summary

cd19184
Location:192 → 335

SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
NM_001369424.1 → NP_001356353.1 histone-lysine N-methyltransferase KMT5B isoform 7

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Related

ENST00000700525.1

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369425.1 → NP_001356354.1 histone-lysine N-methyltransferase KMT5B isoform 8

Status: REVIEWED

Source sequence(s)

AP002992

Consensus CDS

CCDS91519.1

UniProtKB/TrEMBL

B7Z5N2, C9JFG1

Related

ENSP00000403233.2, ENST00000458496.2

Conserved Domains (1) summary

smart00317
Location:132 → 243

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369426.1 → NP_001356355.1 histone-lysine N-methyltransferase KMT5B isoform 1

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS31623.1

UniProtKB/Swiss-Prot

A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393

Conserved Domains (1) summary

cd19184
Location:192 → 335

SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
NM_001369427.1 → NP_001356356.1 histone-lysine N-methyltransferase KMT5B isoform 2

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS44660.1

UniProtKB/TrEMBL

B7Z5N2

Related

ENSP00000385640.1, ENST00000405515.5

Conserved Domains (1) summary

smart00317
Location:203 → 314

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369428.1 → NP_001356357.1 histone-lysine N-methyltransferase KMT5B isoform 3

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369429.1 → NP_001356358.1 histone-lysine N-methyltransferase KMT5B isoform 3

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Related

ENSP00000515030.1, ENST00000700523.1

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369430.1 → NP_001356359.1 histone-lysine N-methyltransferase KMT5B isoform 3

Status: REVIEWED

Source sequence(s)

AP002992

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369431.1 → NP_001356360.1 histone-lysine N-methyltransferase KMT5B isoform 3

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369432.1 → NP_001356361.1 histone-lysine N-methyltransferase KMT5B isoform 3

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_001369433.1 → NP_001356362.1 histone-lysine N-methyltransferase KMT5B isoform 3

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

Consensus CDS

CCDS91518.1

UniProtKB/TrEMBL

A0A8V8TQB9

Conserved Domains (1) summary

smart00317
Location:31 → 142

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_016028.4 → NP_057112.3 histone-lysine N-methyltransferase KMT5B isoform 2

See identical proteins and their annotated locations for NP_057112.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 3' exon and utilizes an upstream stop codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

BC002522, BM152996

Consensus CDS

CCDS44660.1

UniProtKB/TrEMBL

B7Z5N2

Related

ENSP00000385965.2, ENST00000401547.6

Conserved Domains (1) summary

smart00317
Location:203 → 314

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
NM_017635.5 → NP_060105.3 histone-lysine N-methyltransferase KMT5B isoform 1

See identical proteins and their annotated locations for NP_060105.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AP002992, BC099714, BC108304

Consensus CDS

CCDS31623.1

UniProtKB/Swiss-Prot

A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393

Related

ENSP00000305899.4, ENST00000304363.9

Conserved Domains (1) summary

cd19184
Location:192 → 335

SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

RNA

NR_161378.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AP002992, KC877427
NR_161379.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AP002992, KC877427
NR_161380.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AP002992, KC877427

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

68154863..68213648 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047427072.1 → XP_047283028.1 histone-lysine N-methyltransferase KMT5B isoform X4
XM_011545092.4 → XP_011543394.1 histone-lysine N-methyltransferase KMT5B isoform X3

UniProtKB/TrEMBL

C9J6S5

Related

ENSP00000406377.2, ENST00000453170.6

Conserved Domains (1) summary

smart00317
Location:132 → 243

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
XM_005274036.5 → XP_005274093.2 histone-lysine N-methyltransferase KMT5B isoform X2

See identical proteins and their annotated locations for XP_005274093.2

Conserved Domains (1) summary

smart00317
Location:180 → 291

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
XM_005274035.5 → XP_005274092.2 histone-lysine N-methyltransferase KMT5B isoform X1

See identical proteins and their annotated locations for XP_005274092.2

UniProtKB/Swiss-Prot

A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393

Conserved Domains (1) summary

cd19184
Location:192 → 335

SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins
XM_006718581.2 → XP_006718644.1 histone-lysine N-methyltransferase KMT5B isoform X2

See identical proteins and their annotated locations for XP_006718644.1

Conserved Domains (1) summary

smart00317
Location:180 → 291

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
XM_047427071.1 → XP_047283027.1 histone-lysine N-methyltransferase KMT5B isoform X1

UniProtKB/Swiss-Prot

A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393
XM_047427073.1 → XP_047283029.1 histone-lysine N-methyltransferase KMT5B isoform X5
XM_024448570.2 → XP_024304338.1 histone-lysine N-methyltransferase KMT5B isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

68158479..68217261 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054369052.1 → XP_054225027.1 histone-lysine N-methyltransferase KMT5B isoform X4
XM_054369051.1 → XP_054225026.1 histone-lysine N-methyltransferase KMT5B isoform X3

UniProtKB/TrEMBL

C9J6S5
XM_054369049.1 → XP_054225024.1 histone-lysine N-methyltransferase KMT5B isoform X2
XM_054369047.1 → XP_054225022.1 histone-lysine N-methyltransferase KMT5B isoform X1

UniProtKB/Swiss-Prot

A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393
XM_054369050.1 → XP_054225025.1 histone-lysine N-methyltransferase KMT5B isoform X2
XM_054369048.1 → XP_054225023.1 histone-lysine N-methyltransferase KMT5B isoform X1

UniProtKB/Swiss-Prot

A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393
XM_054369053.1 → XP_054225028.1 histone-lysine N-methyltransferase KMT5B isoform X5
XM_054369054.1 → XP_054225029.1 histone-lysine N-methyltransferase KMT5B isoform X5