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    TRIM64B tripartite motif containing 64B [ Homo sapiens (human) ]

    Gene ID: 642446, updated on 17-Jun-2024

    Summary

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    Official Symbol
    TRIM64Bprovided by HGNC
    Official Full Name
    tripartite motif containing 64Bprovided by HGNC
    Primary source
    HGNC:HGNC:37147
    See related
    Ensembl:ENSG00000189253 AllianceGenome:HGNC:37147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See TRIM64B in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89870438..89878487, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89790143..89798190, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89603606..89611655, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 51B, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89592843-89593838 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89593839-89594834 Neighboring gene ANKRD33B pseudogene 8 Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene MT-ND1 pseudogene 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
    2. Human chromosome 11 DNA sequence and analysis including novel gene identification. Taylor TD, et al. Nature, 2006 Mar 23. PMID 16554811
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative tripartite motif-containing protein 64B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164397.3 → NP_001157869.1  putative tripartite motif-containing protein 64B

      See identical proteins and their annotated locations for NP_001157869.1

      Status: VALIDATED

      Source sequence(s)
      AP005435
      Consensus CDS
      CCDS53693.1
      UniProtKB/Swiss-Prot
      A6NI03
      UniProtKB/TrEMBL
      I1YAQ0
      Related
      ENSP00000332969.6, ENST00000329862.7
      Conserved Domains (4) summary
      cd19783
      Location:86 → 138
      Bbox2_TRIM43-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
      pfam05557
      Location:132 → 232
      MAD; Mitotic checkpoint protein
      cd16603
      Location:9 → 67
      RING-HC_TRIM43-like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64 and similar proteins
      cl02614
      Location:284 → 445
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      89870438..89878487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542955.3 → XP_011541257.1  putative tripartite motif-containing protein 64B isoform X1

      Conserved Domains (1) summary
      cl02614
      Location:142 → 303
      SPRY; SPRY domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      89790143..89798190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NI03.3 GenPept UniProtKB/Swiss-Prot:A6NI03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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