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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_028279.2Â RefSeqGene
- Range
-
5064..585269
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1118
mRNA and Protein(s)
-
NM_001105077.4 → NP_001098547.3  histone-lysine N-methyltransferase MECOM isoform a
See identical proteins and their annotated locations for NP_001098547.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes isoform a.
- Source sequence(s)
-
AC078985, BC130520, BX647613
- Consensus CDS
-
CCDS54670.1
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000264674.3, ENST00000264674.7
- Conserved Domains (4) summary
-
- sd00017
Location:800 → 820
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:798 → 820
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:812 → 836
- zf-H2C2_2; Zinc-finger double domain
- cl40432
Location:2 → 80
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
-
NM_001105078.4 → NP_001098548.2  histone-lysine N-methyltransferase MECOM isoform b
See identical proteins and their annotated locations for NP_001098548.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as EVI1_1b) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 7 all encode the same isoform.
- Source sequence(s)
-
AC078985, AK292865, BX647613
- Consensus CDS
-
CCDS3205.1
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000419995.1, ENST00000468789.5
- Conserved Domains (6) summary
-
- PHA00733
Location:689 → 785
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:735 → 755
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:733 → 755
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:747 → 771
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001163999.2 → NP_001157471.1  histone-lysine N-methyltransferase MECOM isoform d
See identical proteins and their annotated locations for NP_001157471.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks a portion of the 5' UTR and 5' coding region, initiates translation at a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
- Source sequence(s)
-
AC078985, BC143952, BX647613
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (4) summary
-
- PHA00733
Location:658 → 777
- PHA00733; hypothetical protein
- sd00017
Location:727 → 747
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:739 → 763
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:164 → 248
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001164000.2 → NP_001157472.1  histone-lysine N-methyltransferase MECOM isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (6, also known as EVI1_1a) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
- Source sequence(s)
-
AC078985, BX640908, BX647613
- Consensus CDS
-
CCDS54669.1
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000419770.1, ENST00000464456.5
- Conserved Domains (5) summary
-
- PHA00733
Location:657 → 776
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:726 → 746
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:738 → 762
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001205194.2 → NP_001192123.1  histone-lysine N-methyltransferase MECOM isoform b
See identical proteins and their annotated locations for NP_001192123.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 7 all encode the same isoform.
- Source sequence(s)
-
BC130520, BX647613, DC347146, GQ352634
- Consensus CDS
-
CCDS3205.1
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (6) summary
-
- PHA00733
Location:689 → 785
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:735 → 755
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:733 → 755
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:747 → 771
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001366466.2 → NP_001353395.1  histone-lysine N-methyltransferase MECOM isoform f
Status: REVIEWED
- Source sequence(s)
-
AC078985, AK308404, AL700380, DC417787
- Consensus CDS
-
CCDS93424.1
- UniProtKB/Swiss-Prot
- A1L4F3, A8KA00, B7Z8W7, B7ZLQ3, B7ZLQ4, C9JAK0, D3DNP7, E7EQ57, Q03112, Q13465, Q13466, Q16122, Q5HYI1, Q6FH90, Q6MZS6, Q8NEI5, Q99917
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000417899.1, ENST00000494292.6
- Conserved Domains (6) summary
-
- PHA00733
Location:845 → 964
- PHA00733; hypothetical protein
- smart00317
Location:80 → 196
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- COG5189
Location:302 → 395
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:914 → 934
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:926 → 950
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:351 → 435
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001366467.2 → NP_001353396.1  histone-lysine N-methyltransferase MECOM isoform g
Status: REVIEWED
- Source sequence(s)
-
AC078985, AK025934
- Consensus CDS
-
CCDS93423.1
- UniProtKB/TrEMBL
- A0A0C3SFZ7, C7FEN9
- Conserved Domains (4) summary
-
- sd00017
Location:736 → 756
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:734 → 756
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:748 → 772
- zf-H2C2_2; Zinc-finger double domain
- cl40432
Location:1 → 16
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
-
NM_001366468.2 → NP_001353397.1  histone-lysine N-methyltransferase MECOM isoform g
Status: REVIEWED
- Source sequence(s)
-
AC078985, CN272058, DA229108, DB222598
- Consensus CDS
-
CCDS93423.1
- UniProtKB/TrEMBL
- A0A0C3SFZ7, C7FEN9
- Conserved Domains (4) summary
-
- sd00017
Location:736 → 756
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:734 → 756
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:748 → 772
- zf-H2C2_2; Zinc-finger double domain
- cl40432
Location:1 → 16
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
-
NM_001366469.2 → NP_001353398.1  histone-lysine N-methyltransferase MECOM isoform b
Status: REVIEWED
- Source sequence(s)
-
AC078985, AK025934
- Consensus CDS
-
CCDS3205.1
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (6) summary
-
- PHA00733
Location:689 → 785
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:735 → 755
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:733 → 755
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:747 → 771
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001366470.2 → NP_001353399.1  histone-lysine N-methyltransferase MECOM isoform d
Status: REVIEWED
- Source sequence(s)
-
AC078985, BC031019
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (4) summary
-
- PHA00733
Location:658 → 777
- PHA00733; hypothetical protein
- sd00017
Location:727 → 747
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:739 → 763
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:164 → 248
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001366471.2 → NP_001353400.1  histone-lysine N-methyltransferase MECOM isoform e
Status: REVIEWED
- Source sequence(s)
-
AC078985, AF487422, DA450456
- Consensus CDS
-
CCDS54669.1
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000420466.1, ENST00000460814.5
- Conserved Domains (5) summary
-
- PHA00733
Location:657 → 776
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:726 → 746
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:738 → 762
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001366472.2 → NP_001353401.1  histone-lysine N-methyltransferase MECOM isoform e
Status: REVIEWED
- Source sequence(s)
-
AC078985
- Consensus CDS
-
CCDS54669.1
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (5) summary
-
- PHA00733
Location:657 → 776
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:726 → 746
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:738 → 762
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_001366473.2 → NP_001353402.1  histone-lysine N-methyltransferase MECOM isoform h
Status: REVIEWED
- Source sequence(s)
-
AC078985, AL700380, BC031019, BG427944, DB225328, DC417787
- Conserved Domains (3) summary
-
- COG5048
Location:289 → 631
- COG5048; FOG: Zn-finger [General function prediction only]
- sd00017
Location:590 → 610
- ZF_C2H2; C2H2 Zn finger [structural motif]
- cd19214
Location:47 → 204
- PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins
-
NM_001366474.2 → NP_001353403.1  histone-lysine N-methyltransferase MECOM isoform i
Status: REVIEWED
- Source sequence(s)
-
AC078985, BF035536, BG427944, BX482681, DA588194, DA738166, DT219127
- Conserved Domains (4) summary
-
- PHA00733
Location:333 → 452
- PHA00733; hypothetical protein
- COG5048
Location:101 → 443
- COG5048; FOG: Zn-finger [General function prediction only]
- sd00017
Location:402 → 422
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam13465
Location:414 → 438
- zf-H2C2_2; Zinc-finger double domain
-
NM_004991.4 → NP_004982.2  histone-lysine N-methyltransferase MECOM isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as MDS1/EVI1) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. There are no publicly available full-length transcripts representing this variant, but it is supported by cloning evidence in PMID:11050005.
- Source sequence(s)
-
AK304098, AL700380, BC130520, BX647613, CR541866, DC348381
- Consensus CDS
-
CCDS93425.1
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000498411.1, ENST00000651503.2
- Conserved Domains (5) summary
-
- smart00317
Location:80 → 196
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- sd00017
Location:923 → 943
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:921 → 943
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:935 → 959
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:351 → 432
- zf-C2H2_8; C2H2-type zinc ribbon
-
NM_005241.4 → NP_005232.2  histone-lysine N-methyltransferase MECOM isoform b
See identical proteins and their annotated locations for NP_005232.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as EVI1_1c) lacks a portion of the 5' UTR and 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 7 all encode the same isoform.
- Source sequence(s)
-
AC078985, BC130520, BX647613, X54989
- Consensus CDS
-
CCDS3205.1
- UniProtKB/TrEMBL
-
C7FEN9
- Related
- ENSP00000486104.1, ENST00000628990.2
- Conserved Domains (6) summary
-
- PHA00733
Location:689 → 785
- PHA00733; hypothetical protein
- COG5189
Location:114 → 207
- SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
- sd00017
Location:735 → 755
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:733 → 755
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:747 → 771
- zf-H2C2_2; Zinc-finger double domain
- pfam15909
Location:163 → 247
- zf-C2H2_8; C2H2-type zinc ribbon
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000003.12Â Reference GRCh38.p14 Primary Assembly
- Range
-
169083507..169663712 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005247214.4 → XP_005247271.1  histone-lysine N-methyltransferase MECOM isoform X2
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (5) summary
-
- PHA00733
Location:846 → 965
- PHA00733; hypothetical protein
- sd00017
Location:915 → 935
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:913 → 935
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:927 → 951
- zf-H2C2_2; Zinc-finger double domain
- cd19214
Location:47 → 204
- PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins
-
XM_005247213.4 → XP_005247270.1  histone-lysine N-methyltransferase MECOM isoform X1
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (4) summary
-
- sd00017
Location:924 → 944
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:922 → 944
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:936 → 960
- zf-H2C2_2; Zinc-finger double domain
- cd19214
Location:47 → 204
- PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins
-
XM_047447690.1 → XP_047303646.1  histone-lysine N-methyltransferase MECOM isoform X16
-
XM_047447688.1 → XP_047303644.1  histone-lysine N-methyltransferase MECOM isoform X14
-
XM_047447682.1 → XP_047303638.1  histone-lysine N-methyltransferase MECOM isoform X9
-
XM_047447679.1 → XP_047303635.1  histone-lysine N-methyltransferase MECOM isoform X6
-
XM_047447689.1 → XP_047303645.1  histone-lysine N-methyltransferase MECOM isoform X15
-
XM_047447680.1 → XP_047303636.1  histone-lysine N-methyltransferase MECOM isoform X7
-
XM_011512546.3 → XP_011510848.1  histone-lysine N-methyltransferase MECOM isoform X5
- UniProtKB/TrEMBL
-
C7FEN9
- Conserved Domains (4) summary
-
- sd00017
Location:808 → 828
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:806 → 828
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:820 → 844
- zf-H2C2_2; Zinc-finger double domain
- cl40432
Location:9 → 88
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
-
XM_047447678.1 → XP_047303634.1  histone-lysine N-methyltransferase MECOM isoform X4
-
XM_047447677.1 → XP_047303633.1  histone-lysine N-methyltransferase MECOM isoform X3
-
XM_047447687.1 → XP_047303643.1  histone-lysine N-methyltransferase MECOM isoform X13
-
XM_005247221.3 → XP_005247278.1  histone-lysine N-methyltransferase MECOM isoform X12
See identical proteins and their annotated locations for XP_005247278.1
- UniProtKB/TrEMBL
- A0A0C3SFZ7, C7FEN9
- Related
- ENSP00000420048.1, ENST00000472280.5
- Conserved Domains (4) summary
-
- sd00017
Location:736 → 756
- ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00096
Location:734 → 756
- zf-C2H2; Zinc finger, C2H2 type
- pfam13465
Location:748 → 772
- zf-H2C2_2; Zinc-finger double domain
- cl40432
Location:1 → 16
- SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
-
XM_047447694.1 → XP_047303650.1  histone-lysine N-methyltransferase MECOM isoform X20
-
XM_047447692.1 → XP_047303648.1  histone-lysine N-methyltransferase MECOM isoform X18
-
XM_047447693.1 → XP_047303649.1  histone-lysine N-methyltransferase MECOM isoform X19
-
XM_047447691.1 → XP_047303647.1  histone-lysine N-methyltransferase MECOM isoform X17
-
XM_047447686.1 → XP_047303642.1  histone-lysine N-methyltransferase MECOM isoform X13
-
XM_047447685.1 → XP_047303641.1  histone-lysine N-methyltransferase MECOM isoform X12
- UniProtKB/TrEMBL
-
A0A0C3SFZ7
-
XM_047447684.1 → XP_047303640.1  histone-lysine N-methyltransferase MECOM isoform X11
-
XM_047447681.1 → XP_047303637.1  histone-lysine N-methyltransferase MECOM isoform X8
-
XM_047447683.1 → XP_047303639.1  histone-lysine N-methyltransferase MECOM isoform X10
Alternate T2T-CHM13v2.0
Genomic
-
NC_060927.1Â Alternate T2T-CHM13v2.0
- Range
-
171867472..172447663 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)