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    UGT2B11 UDP glucuronosyltransferase family 2 member B11 [ Homo sapiens (human) ]

    Gene ID: 10720, updated on 17-Jun-2024

    Summary

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    Official Symbol
    UGT2B11provided by HGNC
    Official Full Name
    UDP glucuronosyltransferase family 2 member B11provided by HGNC
    Primary source
    HGNC:HGNC:12545
    See related
    Ensembl:ENSG00000213759 MIM:603064; AllianceGenome:HGNC:12545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver (RPKM 8.5), gall bladder (RPKM 8.1) and 2 other tissues See more
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    Genomic context

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    See UGT2B11 in Genome Data Viewer
    Location:
    4q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69199951..69224984, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (72640420..72668386, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70065669..70080466, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP-glucuronosyltransferase 2A1-like Neighboring gene MPRA-validated peak5051 silencer Neighboring gene uncharacterized LOC105377267 Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B4 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member B28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11. Beaulieu M, et al. Biochem Biophys Res Commun, 1998 Jul 9. PMID 9675083
    2. Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study. Ohno S, et al. Drug Metab Lett, 2011 Aug. PMID 21679149
    3. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Jin CJ, et al. Biochem Biophys Res Commun, 1993 Jul 15. PMID 8333863
    4. Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays. Li XΑ, et al. Mol Med Rep, 2015 Oct. PMID 26238215, Free PMC Article
    5. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. Li J, et al. Breast Cancer Res, 2010. PMID 20214802, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP3A4, CYP3A7, UGT2B11 and UGT2B15 genes are significantly downregulated in melanosis coli.
      Title: Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
    2. significant expression of UGT2B11 was detected in the liver, breast and kidney, and was clearly different from the distribution of UGT2B28
      Title: Quantitative analysis of UGT2B28 mRNA expression by real-time RT-PCR and application to human tissue distribution study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129611, MGC129612

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic glucuronidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 2B11
    Names
    UDP glucuronosyltransferase 2 family, polypeptide B11
    UDP glycosyltransferase 2 family protein
    UDP glycosyltransferase 2 family, polypeptide B11
    UDPGT 2B11
    NP_001064.1
    XP_011529852.1
    XP_016863149.1
    XP_047305499.1
    XP_054204768.1
    XP_054204769.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001073.3 → NP_001064.1  UDP-glucuronosyltransferase 2B11 precursor

      See identical proteins and their annotated locations for NP_001064.1

      Status: VALIDATED

      Source sequence(s)
      AC111000, AC114797, AF016492, BG184936
      Consensus CDS
      CCDS3527.1
      UniProtKB/Swiss-Prot
      O75310, Q3KNV9
      Related
      ENSP00000387683.1, ENST00000446444.2
      Conserved Domains (1) summary
      pfam00201
      Location:24 → 525
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      69199951..69224984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007660.3 → XP_016863149.1  UDP-glucuronosyltransferase 2B11 isoform X2

    2. XM_047449543.1 → XP_047305499.1  UDP-glucuronosyltransferase 2B11 isoform X2

    3. XM_011531550.3 → XP_011529852.1  UDP-glucuronosyltransferase 2B11 isoform X1

      Conserved Domains (2) summary
      PHA03392
      Location:185 → 423
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24 → 441
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      72640420..72668386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348794.1 → XP_054204769.1  UDP-glucuronosyltransferase 2B11 isoform X2

    2. XM_054348793.1 → XP_054204768.1  UDP-glucuronosyltransferase 2B11 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75310.1 GenPept UniProtKB/Swiss-Prot:O75310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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