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    ANKRD66 ankyrin repeat domain 66 [ Homo sapiens (human) ]

    Gene ID: 100287718, updated on 17-Sep-2024

    Summary

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    Official Symbol
    ANKRD66provided by HGNC
    Official Full Name
    ankyrin repeat domain 66provided by HGNC
    Primary source
    HGNC:HGNC:44669
    See related
    Ensembl:ENSG00000230062 AllianceGenome:HGNC:44669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See ANKRD66 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (46746933..46759506)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (46584578..46597154)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46714670..46727243)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 27 Neighboring gene TDRD6 and SLC25A27 antisense RNA 1 Neighboring gene tudor domain containing 6 Neighboring gene phospholipase A2 group VII Neighboring gene meprin A subunit alpha Neighboring gene NANOG hESC enhancer GRCh37_chr6:46814578-46815142 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene uncharacterized LOC124901488

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162435.3 → NP_001155907.3  ankyrin repeat domain-containing protein 66

      Status: VALIDATED

      Source sequence(s)
      AL161618, AL451143
      Consensus CDS
      CCDS59024.2
      UniProtKB/Swiss-Prot
      B4E2M5
      Related
      ENSP00000454770.2, ENST00000565422.3
      Conserved Domains (2) summary
      sd00045
      Location:10 → 39
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:12 → 104
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      46746933..46759506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010148.2 → XP_016865637.1  ankyrin repeat domain-containing protein 66 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      46584578..46597154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353972.1 → XP_054209947.1  ankyrin repeat domain-containing protein 66 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4E2M5.3 GenPept UniProtKB/Swiss-Prot:B4E2M5

    Gene LinkOut

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