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    Nufip2 nuclear FMR1 interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68564, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nufip2provided by MGI
    Official Full Name
    nuclear FMR1 interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1915814
    See related
    Ensembl:ENSMUSG00000037857 AllianceGenome:MGI:1915814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG1; mKIAA1321; 1110001M19Rik; 9530056D24Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be located in cytosol; nuclear body; and ribosome. Predicted to be active in cytoplasmic stress granule and nucleoplasm. Orthologous to human NUFIP2 (nuclear FMR1 interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.5), bladder adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nufip2 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77576566..77608792)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77685764..77717966)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23132 Neighboring gene STARR-seq mESC enhancer starr_30061 Neighboring gene STARR-seq mESC enhancer starr_30062 Neighboring gene STARR-positive B cell enhancer ABC_E10692 Neighboring gene STARR-seq mESC enhancer starr_30063 Neighboring gene crystallin, beta A1 Neighboring gene STARR-seq mESC enhancer starr_30065 Neighboring gene 60S ribosomal protein L15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization. Bardoni B, et al. Hum Mol Genet, 2003 Jul 15. PMID 12837692
    2. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Rehage N, et al. Nat Commun, 2018 Jan 19. PMID 29352114, Free PMC Article
    3. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
    4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
    5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
      Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FMR1-interacting protein NUFIP2
    Names
    82 kDa FMRP-interacting protein
    82-FIP
    FMRP-interacting protein 2
    proliferation-inducing gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024205.2 → NP_001019376.1  FMR1-interacting protein NUFIP2

      See identical proteins and their annotated locations for NP_001019376.1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS25083.1
      UniProtKB/Swiss-Prot
      Q3TCE2, Q3V195, Q5F2E7, Q80TF1
      Related
      ENSMUSP00000098365.5, ENSMUST00000100802.11
      Conserved Domains (1) summary
      pfam15293
      Location:90 → 685
      NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77576566..77608792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534062.5 → XP_006534125.1  FMR1-interacting protein NUFIP2 isoform X2

      See identical proteins and their annotated locations for XP_006534125.1

      UniProtKB/Swiss-Prot
      Q3TCE2, Q3V195, Q5F2E7, Q80TF1
      Conserved Domains (1) summary
      pfam15293
      Location:90 → 685
      NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

    2. XM_036156930.1 → XP_036012823.1  FMR1-interacting protein NUFIP2 isoform X1

      Conserved Domains (1) summary
      pfam15293
      Location:108 → 700
      NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

    3. XM_006534063.5 → XP_006534126.1  FMR1-interacting protein NUFIP2 isoform X3

      See identical proteins and their annotated locations for XP_006534126.1

      Conserved Domains (1) summary
      pfam15293
      Location:1 → 525
      NUFIP2; Nuclear fragile X mental retardation-interacting protein 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F2E7.1 GenPept UniProtKB/Swiss-Prot:Q5F2E7

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