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    Sel1l sel-1 suppressor of lin-12-like (C. elegans) [ Mus musculus (house mouse) ]

    Gene ID: 20338, updated on 2-Nov-2024

    Summary

    Official Symbol
    Sel1lprovided by MGI
    Official Full Name
    sel-1 suppressor of lin-12-like (C. elegans)provided by MGI
    Primary source
    MGI:MGI:1329016
    See related
    Ensembl:ENSMUSG00000020964 AllianceGenome:MGI:1329016
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sel1h; mKIAA4137
    Summary
    Involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Acts upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; liver; neural tube; pancreas; and spleen. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 18.7), cortex adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sel1l in Genome Data Viewer
    Location:
    12 D3; 12 45.02 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (91772817..91815931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (91806043..91849157, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene stonin 2 Neighboring gene VISTA enhancer mm815 Neighboring gene predicted gene, 16876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:92984674-92984783 Neighboring gene STARR-positive B cell enhancer ABC_E8496 Neighboring gene predicted gene, 34718 Neighboring gene STARR-positive B cell enhancer ABC_E5346 Neighboring gene STARR-positive B cell enhancer ABC_E308 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene motile sperm domain containing 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4137

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Hrd1p ubiquitin ligase ERAD-L complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Hrd1p ubiquitin ligase ERAD-L complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein sel-1 homolog 1
    Names
    Sel1 (suppressor of lin-12) 1 homolog
    sel-1L
    suppressor of lin-12-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039089.1NP_001034178.1  protein sel-1 homolog 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001034178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC157658, AK220502
      Consensus CDS
      CCDS26091.1
      UniProtKB/Swiss-Prot
      Q9DBD8, Q9Z2G6
      UniProtKB/TrEMBL
      Q5DTL8
      Related
      ENSMUSP00000021347.6, ENSMUST00000021347.12
      Conserved Domains (4) summary
      smart00059
      Location:116164
      FN2; Fibronectin type 2 domain
      smart00671
      Location:479514
      SEL1; Sel1-like repeats
      COG0790
      Location:183449
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:389418
      SLR; SLR repeat [structural motif]
    2. NM_011344.2NP_035474.1  protein sel-1 homolog 1 isoform b precursor

      See identical proteins and their annotated locations for NP_035474.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC157658, AK160936, AK220502
      Consensus CDS
      CCDS49137.1
      UniProtKB/TrEMBL
      Q5DTL8, Q6GTY4
      Related
      ENSMUSP00000129384.2, ENSMUST00000167466.2
      Conserved Domains (3) summary
      smart00671
      Location:429464
      SEL1; Sel1-like repeats
      COG0790
      Location:133464
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:339368
      SLR; SLR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      91772817..91815931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)