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    Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 227095, updated on 3-Nov-2024

    Summary

    Official Symbol
    Hibchprovided by MGI
    Official Full Name
    3-hydroxyisobutyryl-Coenzyme A hydrolaseprovided by MGI
    Primary source
    MGI:MGI:1923792
    See related
    Ensembl:ENSMUSG00000041426 AllianceGenome:MGI:1923792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIBYL-COA-H; 2610509I15Rik
    Summary
    Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrolase deficiency. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 20.4), heart adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hibch in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52884197..52960145)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52845038..52920986)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene STARR-seq mESC enhancer starr_00905 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene STARR-seq mESC enhancer starr_00906 Neighboring gene STARR-seq mESC enhancer starr_00907 Neighboring gene myostatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC31364

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3-hydroxyisobutyryl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in valine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
    Names
    HIB-CoA hydrolase
    NP_666220.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146108.2NP_666220.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_666220.1

      Status: VALIDATED

      Source sequence(s)
      AC110177, AK076038, AK082965
      Consensus CDS
      CCDS14948.1
      UniProtKB/Swiss-Prot
      Q8QZS1
      Related
      ENSMUSP00000045606.7, ENSMUST00000044478.7
      Conserved Domains (2) summary
      PRK05617
      Location:33377
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:46374
      ECH_2; Enoyl-CoA hydratase/isomerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52884197..52960145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)