PAQR3 progestin and adipoQ receptor family member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PAQR3provided by HGNC
Official Full Name: progestin and adipoQ receptor family member 3provided by HGNC
Primary source: HGNC:HGNC:30130
See related: Ensembl:ENSG00000163291 MIM:614577; AllianceGenome:HGNC:30130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RKTG
Summary: This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Expression: Broad expression in testis (RPKM 20.7), brain (RPKM 8.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q21.21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (78887076..78939438, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (82222838..82275056, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (79833032..79860592, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
Title: Systematic pan-cancer analyses of the potential function of the Golgi scaffold protein PAQR3.
Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-beta/Smad pathway.
Title: Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway.
Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
Title: Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
Title: PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability.
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Title: PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy.
Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
Title: Associations of the BRAF V600E Mutation and PAQR3 Protein Expression with Papillary Thyroid Carcinoma Clinicopathological Features.
MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
Title: MiR-15b facilitates breast cancer progression via repressing tumor suppressor PAQR3.
PAQR3 might regulate the phosphorylation of FoxO1 and the expressions of GCK and LDLR through NF-kappaB pathway, thereby regulating the glucose and lipid metabolism disorders induced by insulin resistance.
Title: PAQR3 regulates phosphorylation of FoxO1 in insulin-resistant HepG2 cells via NF-κB signaling pathway.
Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation.
Title: Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1.
Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway
Title: Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-24780 (e-PCR)
- UniSTS:27648

SHGC-67756 (e-PCR)
- UniSTS:80592

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SREBP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to Golgi apparatus	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: progestin and adipoQ receptor family member 3

Names: Raf kinase trapping to Golgi; progestin and adipoQ receptor family member III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_053104.1 RefSeqGene

Range

5001..32561

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001040202.2 → NP_001035292.1 progestin and adipoQ receptor family member 3 isoform 1

See identical proteins and their annotated locations for NP_001035292.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC093841, AY424281, BX648346, DA410845

Consensus CDS

CCDS34020.1

UniProtKB/Swiss-Prot

A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9

UniProtKB/TrEMBL

F8W784

Related

ENSP00000421981.1, ENST00000512733.5

Conserved Domains (1) summary

pfam03006
Location:64 → 283

HlyIII; Haemolysin-III related
NM_001350105.2 → NP_001337034.1 progestin and adipoQ receptor family member 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.

Source sequence(s)

AC093841

Conserved Domains (1) summary

cl03831
Location:1 → 165

HlyIII; Haemolysin-III related
NM_001350106.2 → NP_001337035.1 progestin and adipoQ receptor family member 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Both variants 2 and 3 encode the same protein.

Source sequence(s)

AC093841

Conserved Domains (1) summary

cl03831
Location:1 → 165

HlyIII; Haemolysin-III related

RNA

NR_146462.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC093841
NR_146463.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC093841
NR_146464.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC093841
NR_146465.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC093841

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

78887076..78939438 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449645.1 → XP_047305601.1 progestin and adipoQ receptor family member 3 isoform X4
XM_005262769.6 → XP_005262826.1 progestin and adipoQ receptor family member 3 isoform X2

See identical proteins and their annotated locations for XP_005262826.1

UniProtKB/TrEMBL

F8W784

Related

ENSP00000344203.6, ENST00000342820.10

Conserved Domains (1) summary

cl03831
Location:64 → 264

HlyIII; Haemolysin-III related
XM_024453910.2 → XP_024309678.1 progestin and adipoQ receptor family member 3 isoform X3

Conserved Domains (1) summary

cl03831
Location:1 → 165

HlyIII; Haemolysin-III related
XM_047449643.1 → XP_047305599.1 progestin and adipoQ receptor family member 3 isoform X1

UniProtKB/Swiss-Prot

A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9

Related

ENSP00000425080.1, ENST00000511594.5

RNA

XR_938694.4 RNA Sequence
XR_007096371.1 RNA Sequence
XR_007096372.1 RNA Sequence
XR_002959712.2 RNA Sequence
XR_007096373.1 RNA Sequence

Related

ENST00000515853.5

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

82222838..82275056 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348992.1 → XP_054204967.1 progestin and adipoQ receptor family member 3 isoform X4
XM_054348991.1 → XP_054204966.1 progestin and adipoQ receptor family member 3 isoform X3
XM_054348990.1 → XP_054204965.1 progestin and adipoQ receptor family member 3 isoform X1

UniProtKB/Swiss-Prot

A8K5B7, B3KP59, Q6PIQ1, Q6TCH7, Q86X05, Q8NCP9

RNA

XR_008486927.1 RNA Sequence
XR_008486926.1 RNA Sequence
XR_008486925.1 RNA Sequence
XR_008486928.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177453.2: Suppressed sequence

Description

NM_177453.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.