HOTTIP HOXA distal transcript antisense RNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: HOTTIPprovided by HGNC
Official Full Name: HOXA distal transcript antisense RNAprovided by HGNC
Primary source: HGNC:HGNC:37461
See related: MIM:614060; AllianceGenome:HGNC:37461
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HOXA-AS6; HOXA13-AS1; NCRNA00213
Summary: This gene produces a long RNA in antisense to the HOXA gene cluster. This transcript may regulate expression of HOXA genes in cis. This gene is upregulated in tumors and is implicated in the promotion of cell proliferation. [provided by RefSeq, Dec 2017]
Expression: Biased expression in colon (RPKM 4.0), prostate (RPKM 3.7) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p15.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (27200421..27207259)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (27336410..27343254)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (27240040..27246878)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of Genetic Polymorphisms in Long Noncoding RNA HOTTIP with Risk of Idiopathic Recurrent Spontaneous Abortion.
Title: Association of Genetic Polymorphisms in Long Noncoding RNA HOTTIP with Risk of Idiopathic Recurrent Spontaneous Abortion.
Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway.
Title: Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway.
A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling.
Title: A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling.
Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma.
Title: Long non-coding RNA HOTTIP exerts an oncogenic function by regulating HOXA13 in nasopharyngeal carcinoma.
LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
Title: LncRNA HOTTIP promotes inflammatory response in acute gouty arthritis via miR-101-3p/BRD4 axis.
A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma.
Title: A Computationally Constructed lncRNA-Associated Competing Triplet Network in Clear Cell Renal Cell Carcinoma.
Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction.
Title: Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction.
LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
Title: LncRNA HOTTIP facilitates osteogenic differentiation in bone marrow mesenchymal stem cells and induces angiogenesis via interacting with TAF15 to stabilize DLX2.
M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-kappaB pathway.
Title: M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway.
Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1alpha/VEGF signaling.
Title: Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD04443 (e-PCR)
- UniSTS:285515

REN100771 (e-PCR)
- UniSTS:425568

REN100773 (e-PCR)
- UniSTS:425570

REN100774 (e-PCR)
- UniSTS:425571

REN100775 (e-PCR)
- UniSTS:425572

REN100776 (e-PCR)
- UniSTS:425573

REN100777 (e-PCR)
- UniSTS:425574

REN100778 (e-PCR)
- UniSTS:425575

REN100779 (e-PCR)
- UniSTS:425576

REN100780 (e-PCR)
- UniSTS:425577

REN100781 (e-PCR)
- UniSTS:425578

REN100782 (e-PCR)
- UniSTS:425579

ECD02701 (e-PCR)
- UniSTS:283795

ECD04307 (e-PCR)
- UniSTS:285385

stSG609402 (e-PCR)
- UniSTS:449483

ECD05107 (e-PCR)
- UniSTS:286173

Other Names

HOXA cluster antisense RNA 6 (non-protein coding)
HOXA distal transcript antisense RNA (non-protein coding)
HOXA13 antisense RNA 1 (non-protein coding)
HoxA transcript at the distal tip

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables miRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables miRNA inhibitor activity via base-pairing	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lncRNA-mediated post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.