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    KIF13B kinesin family member 13B [ Homo sapiens (human) ]

    Gene ID: 23303, updated on 28-Oct-2024

    Summary

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    Official Symbol
    KIF13Bprovided by HGNC
    Official Full Name
    kinesin family member 13Bprovided by HGNC
    Primary source
    HGNC:HGNC:14405
    See related
    Ensembl:ENSG00000197892 MIM:607350; AllianceGenome:HGNC:14405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAKIN
    Summary
    Enables 14-3-3 protein binding activity and protein kinase binding activity. Involved in regulation of axonogenesis. Located in axon and cytoplasm. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF13B in Genome Data Viewer
    Location:
    8p12
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (29067278..29263388, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (29345440..29541595, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28924795..29120587, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene uncharacterized LOC105379346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:28913988-28915187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27181 Neighboring gene Sharpr-MPRA regulatory region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28924055-28924554 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28927814-28928543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932443-28932946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932947-28933448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28937642-28938205 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28945064-28945235 Neighboring gene MPRA-validated peak6973 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:29063474-29063627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27183 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19069 Neighboring gene uncharacterized LOC124901922 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene uncharacterized LOC124901923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27184 Neighboring gene Sharpr-MPRA regulatory region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:29207199-29207700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:29207701-29208200 Neighboring gene dual specificity phosphatase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transient accumulation and bidirectional movement of KIF13B in primary cilia. Juhl AD, et al. J Cell Sci, 2023 Mar 1. PMID 35403186
    2. An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B. Zhu J, et al. Structure, 2016 Nov 1. PMID 27642159
    3. Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells. Asaba N, et al. J Biol Chem, 2003 Mar 7. PMID 12496241
    4. KIF13B mediates VEGFR2 recycling to modulate vascular permeability. Cho HD, et al. Cell Mol Life Sci, 2023 Mar 16. PMID 36928770, Free PMC Article
    5. Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells. Drabik A, et al. Proteomics Clin Appl, 2020 Jan. PMID 31550741

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF13B mediates VEGFR2 recycling to modulate vascular permeability.
      Title: KIF13B mediates VEGFR2 recycling to modulate vascular permeability.
    2. Transient accumulation and bidirectional movement of KIF13B in primary cilia.
      Title: Transient accumulation and bidirectional movement of KIF13B in primary cilia.
    3. Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells.
      Title: Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells.
    4. Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression.
      Title: KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
    5. Findings show that the high-affinity binding of KIF13B to DLG guanylate kinase (GK) domain does not require phosphorylation of KIF13B and that DLG binds to an unphosphorylated and autonomously folded domain within its stalk region (MAGUK binding stalk [MBS] domain) with high specificity and affinity.
      Title: An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B.
    6. lnc-KIF13B-1, a long non-coding RNA (rs6434720) is associated with corticobasal degeneration.
      Title: Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
    7. KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis.
      Title: KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.
    8. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
      Title: Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation.
      Title: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF13B
    Names
    guanylate kinase associated kinesin
    kinesin 13B
    kinesin-like protein GAKIN

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015254.4 → NP_056069.2  kinesin-like protein KIF13B

      See identical proteins and their annotated locations for NP_056069.2

      Status: VALIDATED

      Source sequence(s)
      AB014539, AC108449, AI760125, DA068190, DA437040
      Consensus CDS
      CCDS55217.1
      UniProtKB/Swiss-Prot
      B4DGY5, B5MC45, F8VPJ2, O75134, Q9BYJ6, Q9NQT8
      Related
      ENSP00000427900.1, ENST00000524189.6
      Conserved Domains (10) summary
      smart00129
      Location:6 → 360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:447 → 544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:1704 → 1767
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:1539 → 1643
      Jun; Jun-like transcription factor
      pfam12423
      Location:756 → 802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1221 → 1279
      DUF3694; Kinesin protein
      pfam16183
      Location:357 → 469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610 → 710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:1099 → 1143
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      29067278..29263388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544459.4 → XP_011542761.1  kinesin-like protein KIF13B isoform X4

      See identical proteins and their annotated locations for XP_011542761.1

      Conserved Domains (11) summary
      smart00129
      Location:9 → 296
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:395 → 508
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:383 → 480
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:3 → 296
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:1661 → 1724
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:1496 → 1600
      Jun; Jun-like transcription factor
      pfam12423
      Location:692 → 738
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1157 → 1215
      DUF3694; Kinesin protein
      pfam16183
      Location:293 → 405
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:546 → 646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:1035 → 1079
      DUF3585; Protein of unknown function (DUF3585)

    2. XM_005273458.2 → XP_005273515.1  kinesin-like protein KIF13B isoform X3

      Conserved Domains (11) summary
      smart00129
      Location:6 → 360
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:459 → 572
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:447 → 544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:1683 → 1746
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:1518 → 1622
      Jun; Jun-like transcription factor
      pfam12423
      Location:756 → 802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1221 → 1279
      DUF3694; Kinesin protein
      pfam16183
      Location:357 → 469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610 → 710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:1099 → 1143
      DUF3585; Protein of unknown function (DUF3585)

    3. XM_011544458.2 → XP_011542760.1  kinesin-like protein KIF13B isoform X2

      Conserved Domains (10) summary
      smart00129
      Location:6 → 360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:447 → 544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:1704 → 1767
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:1539 → 1643
      Jun; Jun-like transcription factor
      pfam12423
      Location:756 → 802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1221 → 1279
      DUF3694; Kinesin protein
      pfam16183
      Location:357 → 469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610 → 710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:1099 → 1143
      DUF3585; Protein of unknown function (DUF3585)

    4. XM_011544457.2 → XP_011542759.1  kinesin-like protein KIF13B isoform X1

      Conserved Domains (10) summary
      smart00129
      Location:6 → 360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:447 → 544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4 → 360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:1725 → 1788
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:1560 → 1664
      Jun; Jun-like transcription factor
      pfam12423
      Location:756 → 802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1221 → 1279
      DUF3694; Kinesin protein
      pfam16183
      Location:357 → 469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610 → 710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:1099 → 1143
      DUF3585; Protein of unknown function (DUF3585)

    5. XM_047421619.1 → XP_047277575.1  kinesin-like protein KIF13B isoform X4

    6. XM_011544460.4 → XP_011542762.1  kinesin-like protein KIF13B isoform X4

      See identical proteins and their annotated locations for XP_011542762.1

      Conserved Domains (11) summary
      smart00129
      Location:9 → 296
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:395 → 508
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:383 → 480
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:3 → 296
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:1661 → 1724
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:1496 → 1600
      Jun; Jun-like transcription factor
      pfam12423
      Location:692 → 738
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:1157 → 1215
      DUF3694; Kinesin protein
      pfam16183
      Location:293 → 405
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:546 → 646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:1035 → 1079
      DUF3585; Protein of unknown function (DUF3585)

    7. XM_017013257.2 → XP_016868746.1  kinesin-like protein KIF13B isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      29345440..29541595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360193.1 → XP_054216168.1  kinesin-like protein KIF13B isoform X4

    2. XM_054360191.1 → XP_054216166.1  kinesin-like protein KIF13B isoform X3

    3. XM_054360190.1 → XP_054216165.1  kinesin-like protein KIF13B isoform X2

    4. XM_054360189.1 → XP_054216164.1  kinesin-like protein KIF13B isoform X1

    5. XM_054360194.1 → XP_054216169.1  kinesin-like protein KIF13B isoform X4

    6. XM_054360192.1 → XP_054216167.1  kinesin-like protein KIF13B isoform X4

    7. XM_054360195.1 → XP_054216170.1  kinesin-like protein KIF13B isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NQT8.2 GenPept UniProtKB/Swiss-Prot:Q9NQT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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