pod1 pod1 coronin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pod1provided by FlyBase
Official Full Name: pod1 coroninprovided by FlyBase
Primary source: FLYBASE:FBgn0029903
Locus tag: Dmel_CG4532
See related: AllianceGenome:FB:FBgn0029903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD08951; BEST:LD37601; CG4532; Dmel\CG4532; dmPod; dpod1; Dpod1; DPod1; pod-1; Pod-1; POD-1; Pod1
Summary: Enables actin filament binding activity; microtubule binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including AMPA glutamate receptor clustering; axon guidance; and positive regulation of hippo signaling. Located in growth cone and neuromuscular junction. Colocalizes with actin filament and cytoplasmic microtubule. Is expressed in several structures, including CNS glial cell; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Used to study obesity. Orthologous to human CORO7 (coronin 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 6D2-6D3; 1-18 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (6803684..6813830)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (6697717..6707863)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Actin-microtubule crosslinker Pod-1 tunes PAR-1 signaling to control synaptic development and tau-mediated synaptic toxicity.
Title: Actin-microtubule crosslinker Pod-1 tunes PAR-1 signaling to control synaptic development and tau-mediated synaptic toxicity.
Knocking down pod1 in Drosophila adult nervous system increased resistance to starvation; feeding flies a high-calorie diet increased pod1 expression; conclude that coronin 7 is involved in regulation of energy homeostasis and this role stems, to some degree, from the effect on feeding for calories and reward
Title: Implication of coronin 7 in body weight regulation in humans, mice and flies.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pod1 coronin

Names: CG4532-PA; CG4532-PB; CG4532-PC; CG4532-PD; CG4532-PE; CG4532-PF; CG4532-PG; POD-1/coronin; coronin; pod1-PA; pod1-PB; pod1-PC; pod1-PD; pod1-PE; pod1-PF; pod1-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

6803684..6813830

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258625.2 → NP_001245554.1 pod1 coronin, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245554.1

Status: REVIEWED

UniProtKB/TrEMBL

D6W4T8

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:1146 → 1189

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:843 → 1116

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167091.3 → NP_727125.1 pod1 coronin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727125.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3W1

Related

FBpp0070925

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:954 → 997

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:651 → 924

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001103427.3 → NP_001096897.1 pod1 coronin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096897.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JV09

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:1135 → 1178

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:832 → 1105

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167092.3 → NP_727126.1 pod1 coronin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727126.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3W1

Related

FBpp0070926

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:954 → 997

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:651 → 924

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167093.2 → NP_727127.1 pod1 coronin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727127.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3W1

Related

FBpp0070927

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:954 → 997

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:651 → 924

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_132124.5 → NP_572352.1 pod1 coronin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572352.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3W1

Related

FBpp0070928

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:954 → 997

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:651 → 924

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_167094.2 → NP_727128.1 pod1 coronin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727128.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W3W1

Related

FBpp0070929

Conserved Domains (4) summary

pfam08953
Location:6 → 62

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:954 → 997

WD40_4; Type of WD40 repeat

sd00039
Location:83 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:651 → 924

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...