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    CG30440 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35496, updated on 4-Jul-2024

    Summary

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    Official Symbol
    CG30440provided by FlyBase
    Primary source
    FLYBASE:FBgn0050440
    Locus tag
    Dmel_CG30440
    See related
    AllianceGenome:FB:FBgn0050440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10412; CG10416; CG12183; Dmel\CG30440
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic optic lobe primordium; germline cell; and presumptive embryonic/larval system. Orthologous to several human genes including MCF2 (MCF.2 cell line derived transforming sequence). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG30440 in Genome Data Viewer
    Location:
    41F2-41F2; 2-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5468319..5495861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1355824..1383366, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42646 Neighboring gene straw Neighboring gene UDP-glycosyltransferase family 50 member B3 Neighboring gene Troponin C isoform 4 Neighboring gene Fission, mitochondrial 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests. Saha S, et al. Nucleic Acids Res, 2022 Oct 28. PMID 36107776, Free PMC Article
    2. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
    3. Functional antagonism between histone H3K4 demethylases in vivo. Di Stefano L, et al. Genes Dev, 2011 Jan 1. PMID 21205864, Free PMC Article
    4. Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction. Myster SH, et al. Genetics, 2004 Feb. PMID 15020470, Free PMC Article
    5. Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Rehwinkel J, et al. Nat Struct Mol Biol, 2004 Jun. PMID 15133499

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5474186-5473822 mobile_element_type = transposon:INE-1{}4247
    • Loc: c5474421-5474263 mobile_element_type = transposon:Q{}5054
    • Loc: c5474556-5474432 mobile_element_type = transposon:Cr1a{}4406
    • Loc: c5477393-5475953 mobile_element_type = transposon:jockey2{}3401
    • Loc: c5479226-5479100 mobile_element_type = transposon:Fw2{}5038
    • Loc: c5480476-5478930 mobile_element_type = transposon:F{}4320
    • Loc: c5481412-5481308 mobile_element_type = transposon:Rt1c{}4477
    • Loc: c5482708-5480644 mobile_element_type = transposon:G5A{}4360
    • Loc: c5483424-5482712 mobile_element_type = transposon:G5{}4447
    • Loc: c5492869-5492497 mobile_element_type = transposon:INE-1{}4258

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30440-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5468319..5495861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136328.3 → NP_610172.1  uncharacterized protein Dmel_CG30440 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4E0
      Related
      FBpp0085412
      Conserved Domains (3) summary
      smart00325
      Location:622 → 796
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      pfam00169
      Location:829 → 922
      PH; PH domain
      cl17171
      Location:802 → 925
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4E0 Q7K4E0

    Gene LinkOut

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