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    chn charlatan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36678, updated on 2-Nov-2024

    Summary

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    Official Symbol
    chnprovided by FlyBase
    Official Full Name
    charlatanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015371
    Locus tag
    Dmel_CG11798
    See related
    AllianceGenome:FB:FBgn0015371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.13; CG11798; chl; Chn; clone 1.13; Dmel\CG11798; EPIL#6; EPIL6; l(2)02064; l(2)k04218; taco
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including larval somatic muscle development; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; brain; head epidermis primordium; imaginal disc; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See chn in Genome Data Viewer
    Location:
    51E1-51E2; 2-74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15115236..15144783)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11002741..11032288)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44457 Neighboring gene RNA polymerase II, I and III subunit K Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A splicing variant of Charlatan, a Drosophila REST-like molecule, preferentially localizes to axons. Yamasaki Y, et al. Biochem Biophys Res Commun, 2021 Nov 12. PMID 34536827
    2. Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. Yamasaki Y, et al. Genes Cells, 2011 Aug. PMID 21762412
    3. Hindsight modulates Delta expression during Drosophila cone cell induction. Pickup AT, et al. Development, 2009 Mar. PMID 19234063
    4. Drosophila Cellular Immunity Against Parasitoid Wasps: A Complex and Time-Dependent Process. Kim-Jo C, et al. Front Physiol, 2019. PMID 31156469, Free PMC Article
    5. The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling. Artero RD, et al. Development, 2001 Nov. PMID 11684661

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.
      Title: Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.
    2. Chn is a dual functional regulator of transcription.
      Title: Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy.
    3. Data show that isolated plasmatocytes can be triggered to differentiate into lamellocytes in vitro, either in response to Chn over-expression, or following activation of the JAK/STAT pathway.
      Title: Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity.
    4. under EGF signaling, double negative regulation mediated by the Ebi/SMRTER corepressor complex and an NRSF/REST-like factor, Chn, maintains inductive activity in developing photoreceptor cells by promoting Dl expression
      Title: An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila.
    5. mutation decreases the accumulation of Sc in proneural clusters, affecting notum macrochaetae, overexpression enhances ac/sc
      Title: Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 15119372-15127796 mobile_element_type = transposon:Tirant{}833

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of compound eye cone cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in progression of morphogenetic furrow involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    charlatan
    Names
    CG11798-PA
    CG11798-PB
    CG11798-PC
    CG11798-PD
    CG11798-PE
    CG11798-PF
    CG11798-PG
    CG11798-PH
    CG11798-PI
    chn-PA
    chn-PB
    chn-PC
    chn-PD
    chn-PE
    chn-PF
    chn-PG
    chn-PH
    chn-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15115236..15144783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043082.2 → NP_001036547.1  charlatan, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH6, Q0E968, Q5BHY4, Q7YU81, Q8T065, Q95RE7, Q9V788
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_206119.2 → NP_995841.1  charlatan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU81
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001259402.2 → NP_001246331.1  charlatan, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A3
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001259405.2 → NP_001246334.1  charlatan, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Q9
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001043081.2 → NP_001036546.1  charlatan, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036546.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU81
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001259403.2 → NP_001246332.1  charlatan, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A3
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001259401.2 → NP_001246330.1  charlatan, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Z6
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001259404.2 → NP_001246333.1  charlatan, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K876
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_137169.4 → NP_611013.1  charlatan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU81
      Related
      FBpp0086546
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7A3 A0A0B4K7A3
    A0A0B4K7Q9 A0A0B4K7Q9
    A0A0B4K7Z6 A0A0B4K7Z6
    A0A0B4K876 A0A0B4K876
    Q7YU81.3 Q7YU81

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