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    Tsp26A Tetraspanin 26A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33838, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tsp26Aprovided by FlyBase
    Official Full Name
    Tetraspanin 26Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031760
    Locus tag
    Dmel_CG9093
    See related
    AllianceGenome:FB:FBgn0031760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9093; Dm.Tsp26A; Dmel\CG9093; tsp26A
    Summary
    Involved in intracellular transport and positive regulation of Notch signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TSPAN14 (tetraspanin 14); TSPAN17 (tetraspanin 17); and TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp26A in Genome Data Viewer
    Location:
    26B2-26B2; 2-18 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6000228..6003738)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6000228..6003738)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene infertile crescent Neighboring gene Lysine demethylase 5 Neighboring gene antisense RNA:CR43866 Neighboring gene beta galactosidase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    2. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article
    3. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. Dornier E, et al. J Cell Biol, 2012 Oct 29. PMID 23091066, Free PMC Article
    4. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    5. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 26A
    Names
    CG9093-PB
    CG9093-PC
    CG9093-PD
    Tsp26A-PB
    Tsp26A-PC
    Tsp26A-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6000228..6003738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103623.4 → NP_001097093.1  tetraspanin 26A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KF8, Q9VMJ6
      Conserved Domains (3) summary
      cd03159
      Location:118 → 239
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18 → 253
      Tetraspannin; Tetraspanin family
      cl19878
      Location:65 → 157
      DUF2207; Predicted membrane protein (DUF2207)

    2. NM_001273190.1 → NP_001260119.1  tetraspanin 26A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260119.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCP6, Q32KF8
      Conserved Domains (3) summary
      cd03159
      Location:118 → 239
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18 → 263
      Tetraspannin; Tetraspanin family
      cl19878
      Location:65 → 157
      DUF2207; Predicted membrane protein (DUF2207)

    3. NM_001258982.2 → NP_001245911.1  tetraspanin 26A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NCS1, Q32KF8
      Conserved Domains (3) summary
      cd03159
      Location:118 → 241
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18 → 265
      Tetraspannin; Tetraspanin family
      cl19878
      Location:65 → 157
      DUF2207; Predicted membrane protein (DUF2207)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NCS1 M9NCS1
    M9PCP6 M9PCP6
    Q9VMJ6 Q9VMJ6

    Gene LinkOut

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