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    Gld Glucose dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40875, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Gldprovided by FlyBase
    Official Full Name
    Glucose dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001112
    Locus tag
    Dmel_CG1152
    See related
    AllianceGenome:FB:FBgn0001112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1152; Dmel\CG1152; GDH; gld; GLD; glucose dehydrogenase; Go; l(3)84Cg
    Summary
    Predicted to enable oxidoreductase activity. Involved in sperm storage. Is expressed in several structures, including ejaculatory duct; embryonic epidermis; embryonic/larval posterior spiracle; foregut; and ventral sensory complex primordium. Orthologous to human CHDH (choline dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gld in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7252063..7265703, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3077785..3091425, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DTW domain containing 2 Neighboring gene Odorant-binding protein 84a Neighboring gene long non-coding RNA:CR44338 Neighboring gene Synaptotagmin 4 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. Iida K, et al. J Exp Biol, 2004 Feb. PMID 14718510
    2. Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster. Cavener DR. Biochem Genet, 1980 Oct. PMID 6784715
    3. Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster. Cavener DR, et al. Proc Natl Acad Sci U S A, 1983 Oct. PMID 6413974, Free PMC Article
    4. Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster. Cox-Foster DL, et al. Genetics, 1990 Apr. PMID 2108903, Free PMC Article
    5. Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes. Cavener DR, et al. Mol Biol Evol, 1991 Jan. PMID 2002763

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose dehydrogenase (FAD, quinone) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pupal chitin-based cuticle development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sperm storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm storage TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose dehydrogenase
    Names
    CG1152-PA
    CG1152-PB
    Gld-PA
    Gld-PB
    glucose oxidase
    NP_001350861.1
    NP_477503.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7252063..7265703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001363924.1 → NP_001350861.1  glucose dehydrogenase, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P18173, Q9VI87
      UniProtKB/TrEMBL
      A0A2U8U0K3
      Conserved Domains (2) summary
      cl27052
      Location:64 → 601
      GMC_oxred_C; GMC oxidoreductase
      cl27343
      Location:29 → 95
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

    2. NM_058155.5 → NP_477503.1  glucose dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXV0, U3PT72
      Related
      FBpp0081114
      Conserved Domains (3) summary
      PRK02106
      Location:64 → 601
      PRK02106; choline dehydrogenase; Validated
      pfam00732
      Location:130 → 361
      GMC_oxred_N; GMC oxidoreductase
      pfam05199
      Location:456 → 599
      GMC_oxred_C; GMC oxidoreductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2U8U0K3 A0A2U8U0K3
    P18173.3 P18173
    Q8SXV0 Q8SXV0

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