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    Trpm Transient receptor potential cation channel, subfamily M [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36694, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trpmprovided by FlyBase
    Official Full Name
    Transient receptor potential cation channel, subfamily Mprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265194
    Locus tag
    Dmel_CG44240
    See related
    AllianceGenome:FB:FBgn0265194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04950; CG16805; CG30078; CG30079; CG34123; CG34187; CG44240; Dmel\CG44240; DmTRPM; dTRPM; mdcds_11815; trpm; TrpM; TRPM
    Old locus tag
    Dmel_CG34123
    Summary
    Enables intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity and zinc ion transmembrane transporter activity. Involved in intracellular zinc ion homeostasis; magnesium ion homeostasis; and monoatomic cation transport. Part of cation channel complex. Is expressed in several structures, including Malpighian tubule; adult head; embryonic anal pad; embryonic/larval Malpighian tubule Type I cell; and spermatozoon. Used to study chromosome 15q13.3 microdeletion syndrome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; congenital stationary night blindness (multiple); and metal metabolism disorder (multiple). Orthologous to several human genes including TRPM3 (transient receptor potential cation channel subfamily M member 3); TRPM6 (transient receptor potential cation channel subfamily M member 6); and TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Trpm in Genome Data Viewer
    Location:
    51E11-51F4; 2-74 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15262808..15309368, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11150313..11196873, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44370 Neighboring gene Follistatin Neighboring gene scab Neighboring gene Integrin alphaPS4 subunit Neighboring gene long non-coding RNA:CR44241 Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2 Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum, complementation group C Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila TRPM channel is essential for the control of extracellular magnesium levels. Hofmann T, et al. PLoS One, 2010 May 6. PMID 20463899, Free PMC Article
    2. Regulation of Trpm activation and calcium wave initiation during Drosophila egg activation. Hu Q, et al. Mol Reprod Dev, 2020 Aug. PMID 32735035, Free PMC Article
    3. Drosophila menthol sensitivity and the Precambrian origins of transient receptor potential-dependent chemosensation. Himmel NJ, et al. Philos Trans R Soc Lond B Biol Sci, 2019 Nov 11. PMID 31544603, Free PMC Article
    4. Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. Feng X, et al. J Biol Chem, 2014 Feb 14. PMID 24375408, Free PMC Article
    5. Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release. Razzell W, et al. Curr Biol, 2013 Mar 4. PMID 23394834, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Trpm activation and calcium wave initiation during Drosophila egg activation.
      Title: Regulation of Trpm activation and calcium wave initiation during Drosophila egg activation.
    2. identify the Transient Receptor Potential (TRP) channel subfamily M (Trpm) as a critical channel that mediates the calcium influx and initiates the calcium wave during Drosophila egg activation
      Title: The Drosophila Trpm channel mediates calcium influx during egg activation.
    3. These data provide the first evidence for a role for a Drosophila TRP channel in Mg2+ homeostasis, and underscore a broad and evolutionarily conserved role for TRPM channels in Mg2+ homeostasis.
      Title: Drosophila TRPM channel is essential for the control of extracellular magnesium levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inorganic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metal ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transient receptor potential cation channel, subfamily M
    Names
    CG44240-PA
    CG44240-PB
    CG44240-PD
    CG44240-PE
    CG44240-PF
    CG44240-PG
    CG44240-PH
    CG44240-PI
    CG44240-PJ
    CG44240-PK
    CG44240-PL
    Trpm-PA
    Trpm-PB
    Trpm-PD
    Trpm-PE
    Trpm-PF
    Trpm-PG
    Trpm-PH
    Trpm-PI
    Trpm-PJ
    Trpm-PK
    Trpm-PL
    transient receptor potential cation channel, subfamily M ortholog
    transient receptor potential channel M

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15262808..15309368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144200.2 → NP_001137672.2  transient receptor potential cation channel, subfamily M, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137672.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZH4
      Conserved Domains (2) summary
      pfam00520
      Location:867 → 1083
      Ion_trans; Ion transport protein
      pfam16519
      Location:1178 → 1229
      TRPM_tetra; Tetramerization domain of TRPM

    2. NM_001414108.1 → NP_001401006.1  transient receptor potential cation channel, subfamily M, isoform K [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_001299517.1 → NP_001286446.1  transient receptor potential cation channel, subfamily M, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGJ2
      Conserved Domains (2) summary
      pfam00520
      Location:896 → 1112
      Ion_trans; Ion transport protein
      pfam16519
      Location:1207 → 1258
      TRPM_tetra; Tetramerization domain of TRPM

    4. NM_001414109.1 → NP_001401007.1  transient receptor potential cation channel, subfamily M, isoform L [Drosophila melanogaster]

      Status: REVIEWED

    5. NM_001144201.2 → NP_001137673.1  transient receptor potential cation channel, subfamily M, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZH3
      Conserved Domains (2) summary
      pfam00520
      Location:856 → 1072
      Ion_trans; Ion transport protein
      pfam16519
      Location:1167 → 1218
      TRPM_tetra; Tetramerization domain of TRPM

    6. NM_001299518.1 → NP_001286447.1  transient receptor potential cation channel, subfamily M, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286447.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFE7
      Conserved Domains (2) summary
      pfam00520
      Location:881 → 1097
      Ion_trans; Ion transport protein
      pfam16519
      Location:1192 → 1243
      TRPM_tetra; Tetramerization domain of TRPM

    7. NM_001299519.1 → NP_001286448.1  transient receptor potential cation channel, subfamily M, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF73
      Conserved Domains (2) summary
      pfam00520
      Location:830 → 1046
      Ion_trans; Ion transport protein
      pfam16519
      Location:1141 → 1192
      TRPM_tetra; Tetramerization domain of TRPM

    8. NM_001043084.2 → NP_001036549.1  transient receptor potential cation channel, subfamily M, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYE2
      Conserved Domains (2) summary
      pfam00520
      Location:849 → 1065
      Ion_trans; Ion transport protein
      pfam16519
      Location:1160 → 1211
      TRPM_tetra; Tetramerization domain of TRPM

    9. NM_001043085.2 → NP_001036550.2  transient receptor potential cation channel, subfamily M, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036550.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYE2
      Conserved Domains (2) summary
      pfam00520
      Location:849 → 1140
      Ion_trans; Ion transport protein
      pfam16519
      Location:1235 → 1286
      TRPM_tetra; Tetramerization domain of TRPM

    10. NM_001103850.2 → NP_001097320.1  transient receptor potential cation channel, subfamily M, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z9Z5, A8DYE2, Q0E967, Q7K1C1
      Conserved Domains (2) summary
      pfam00520
      Location:951 → 1167
      Ion_trans; Ion transport protein
      pfam16519
      Location:1262 → 1313
      TRPM_tetra; Tetramerization domain of TRPM

    11. NM_001043083.2 → NP_001036548.1  transient receptor potential cation channel, subfamily M, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYE2
      Conserved Domains (1) summary
      pfam00520
      Location:849 → 1065
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF73 A0A0B4LF73
    A0A0B4LFE7 A0A0B4LFE7
    A0A0B4LGJ2 A0A0B4LGJ2
    A8DYE2.1 A8DYE2
    B2N016 B2N016
    B7YZH3 B7YZH3
    B7YZH4 B7YZH4

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