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    CG32369 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38873, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CG32369provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052369
    Locus tag
    Dmel_CG32369
    See related
    AllianceGenome:FB:FBgn0052369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13684; CG7388; Dmel\CG32369
    Summary
    Predicted to enable zinc ion binding activity. Is expressed in embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval visceral muscle cell; and longitudinal visceral muscle primordium. Orthologous to several human genes including LONRF2 (LON peptidase N-terminal domain and ring finger 2) and LONRF3 (LON peptidase N-terminal domain and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG32369 in Genome Data Viewer
    Location:
    66A13-66A14; 3-21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7777105..7809825, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7770205..7802925, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Henna Neighboring gene Clock Neighboring gene PAR-domain protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Terriente-Felix A, et al. Development, 2013 Feb. PMID 23325760, Free PMC Article
    2. Genome-wide identification of hypoxia-induced enhancer regions. Kamps-Hughes N, et al. PeerJ, 2015. PMID 26713262, Free PMC Article
    3. Transcriptome analysis of Drosophila melanogaster laboratory strains of different geographical origin after long-term laboratory maintenance. Zarubin M, et al. Ecol Evol, 2020 Jul. PMID 32760513, Free PMC Article
    4. RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides. Abruzzi KC, et al. PLoS Genet, 2017 Feb. PMID 28182648, Free PMC Article
    5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c7800761-7793767 mobile_element_type = transposon:297{}950

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32369-PA
    CG32369-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7777105..7809825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259731.3 → NP_001246660.1  uncharacterized protein Dmel_CG32369, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG83, Q9VSB2
      Conserved Domains (6) summary
      cd00162
      Location:687 → 729
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl19481
      Location:791 → 1005
      LON; Found in ATP-dependent protease La (LON)
      sd00006
      Location:350 → 378
      TPR; TPR repeat [structural motif]
      pfam02190
      Location:802 → 1001
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
      pfam13414
      Location:349 → 412
      TPR_11; TPR repeat
      cl17238
      Location:183 → 206
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_168232.3 → NP_729296.1  uncharacterized protein Dmel_CG32369, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG83, Q9VSB2
      Related
      FBpp0076498
      Conserved Domains (6) summary
      cd00162
      Location:687 → 729
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl19481
      Location:791 → 1005
      LON; Found in ATP-dependent protease La (LON)
      sd00006
      Location:350 → 378
      TPR; TPR repeat [structural motif]
      pfam02190
      Location:802 → 1001
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
      pfam13414
      Location:349 → 412
      TPR_11; TPR repeat
      cl17238
      Location:183 → 206
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IG83 Q8IG83
    Q9VSB1 Q9VSB1
    Q9VSB2 Q9VSB2

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